Impact of nausea/vomiting on quality of life as a visual analogue scale-derived utility score

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Steven M GrunbergT Ashikaga

Abstract

Pharmacoeconomic analysis is often based upon incremental cost per increase in survival (cost-effectiveness). Using this definition supportive care measures, which increase quality but not quantity of life, generate a zero denominator and cannot be directly compared with other components of health care cost. Cost-utility analysis, which measures incremental cost per increase in quality-adjusted life-years (QALY), where QALY = utility score x time at risk, addresses this problem, since successful supportive intervention increases the utility score and thus provides a finite denominator in QALY even when absolute survival is unchanged. However, utility scores for various supportive care modalities have not been well defined. As a pilot study to generate a first approximation of a utility score for nausea/vomiting, we used a rating scale technique and administered two visual analogue scale questions to 30 patients completing a cycle of chemotherapy. Patients rated their global quality of life during their previous cycle of chemotherapy with hypothetical absence or presence of nausea/vomiting as the only variable. The study population included 8 male and 22 female patients, with a median age of 56 years. The most common malignancie...Continue Reading

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Citations

Nov 13, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Charlotte C SunEdward B Rubenstein
Dec 24, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Muneer H AbidiJoseph Uberti
Nov 30, 2002·Journal of Pain and Symptom Management·Sussanne BörjesonGunnar Steineck
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Dec 3, 2011·The Oncologist·Luke J PepponeScott McIntosh
Oct 19, 2010·Expert Review of Pharmacoeconomics & Outcomes Research·Tessa PeasgoodJohn Brazier
May 24, 2011·Seminars in Oncology·Emma Bateman, Dorothy Keefe
Dec 1, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Florian LordickRobert Deuson
Feb 7, 2006·The Journal of Pain : Official Journal of the American Pain Society·M Soledad Cepeda, John T Farrar
Jan 31, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Alan BrennanVictoria Abbott
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Feb 3, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ikuto TsukiyamaAkihito Kubo
Nov 9, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jeong Eun KimKyung Wan Min
Feb 24, 2001·Gastroenterology·E M QuigleyH P Parkman
Oct 25, 2017·Current Problems in Cancer·Mihoko MoritaTakanori Ueda

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