Impact of Neoadjuvant Radiotherapy on Complications After Hartmann Procedure for Rectal Cancer

Diseases of the Colon and Rectum
Frederik H W JonkerDutch Surgical Colorectal Audit group

Abstract

The effects of neoadjuvant radiotherapy on healing of the rectal stump after a Hartmann procedure for rectal cancer are unknown. The purpose of this study was to analyze the impact of radiotherapy on postoperative complications after a Hartmann procedure for rectal cancer at a population level. This was a population-based observational study. Postoperative outcomes were compared between Hartmann procedures with and without radiotherapy. Risk factors for postoperative intra-abdominal abscess requiring reintervention, any reintervention, and 30-day or in-hospital mortality were analyzed using a multivariable model. The study included in-hospital registration for the Dutch Surgical Colorectal Audit. Patients with rectal cancer who underwent a Hartmann procedure (total or partial mesorectal excision with end colostomy) between 2009 and 2013 were included. Abdominal abscess requiring reintervention, any reintervention, and 30-day or in-hospital mortality were measured. Of 1728 patients who underwent a Hartmann procedure for rectal cancer, 90.5% (n = 1563) received preoperative radiotherapy. Intra-abdominal abscess formation was significantly increased after radiotherapy (7.0% vs 3.0%; p = 0.049). Overall reinterventions (15.2% vs 15...Continue Reading

References

Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A M MarijnenUNKNOWN Cooperative Investigators of the Dutch Colorectal Cancer Group
Jul 3, 2004·ANZ Journal of Surgery·John N R FryeFrank A Frizelle
Feb 17, 2005·Diseases of the Colon and Rectum·Anders Tøttrup, Lise Frost
Jun 4, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P P TekkisUNKNOWN Association of Coloproctology of Great Britain and Ireland
Jun 4, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K BujkoUNKNOWN Polish Colorectal Study Group
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joakim FolkessonUlf Gunnarsson
Sep 15, 2006·The New England Journal of Medicine·Jean-François BossetUNKNOWN EORTC Radiotherapy Group Trial 22921
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre GérardLaurent Bedenne
Feb 23, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A G ElferinkUNKNOWN Working Group Output of the Netherlands Cancer Registry
Jun 22, 2010·International Journal of Colorectal Disease·Laura A HealyJohn V Reynolds
Jul 7, 2011·Diseases of the Colon and Rectum·José Luis Molina RodríguezEduardo García-Granero
Dec 15, 2012·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·S SalmenkyläUNKNOWN Finnish Rectal Cancer Trial Group
Jul 3, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N J van LeersumUNKNOWN Dutch Surgical Colorectal Cancer Audit Group
Jul 23, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N J Van LeersumD Boerma
Jan 28, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M RutegårdJ Rutegård
Jun 6, 2014·Diseases of the Colon and Rectum·Hector OrtizUNKNOWN Spanish Rectal Cancer Project
Aug 8, 2014·Diseases of the Colon and Rectum·Gijsbert D MustersPieter J Tanis

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Citations

Apr 27, 2016·Journal of the American College of Surgeons·Stefan D HolubarS Joga Ivatury
Mar 5, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·UNKNOWN Dutch Snapshot Research Group
Nov 27, 2018·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M PopiolekP Matthiessen
Jan 23, 2018·International Journal of Colorectal Disease·Ingvar SverrissonKenneth Smedh
Aug 13, 2017·International Journal of Colorectal Disease·Emma WesterduinPieter J Tanis
May 30, 2019·World Journal of Gastrointestinal Oncology·Tian-Cheng ZhanMing Li
Mar 25, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E WesterduinUNKNOWN Dutch Snapshot Research Group
Jul 18, 2021·International Journal of Colorectal Disease·Nasir Zaheer AhmadJohn Calvin Coffey

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