Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer's disease.

Journal of Neurochemistry
Bo LiWei Zhang

Abstract

Small extracellular vesicles (EVs), including exosomes, play multiple physiological roles. In neurodegenerative diseases, EVs can be pivotal in dispersing neuropathogenic proteins. This study investigates the role of neural stem cell (NSC)-derived EVs in a transgenic (Tg) mouse model of Alzheimer's disease (AD). Five weeks following treatment on 9-month-old APP/PS1 mice, the effects of NSC-derived EVs on cognitive behavior, mitochondrial function, sirtuin1 (SIRT1), synaptic function and morphology, quantification of amyloid-β (Aβ) level, and inflammatory response were investigated. The results showed that mice in the Tg-NSCs-ev group exhibited significant improvement in cognitive performance compared with Tg-Veh group. Furthermore, the expression of mitochondrial function-related factors (peroxisome proliferator-activated receptor-γ coactivator-1α [PGC1α], nuclear respiratory factor 1 and 2 [NRF1 and 2], and fission 1 [Fis1]), SIRT1 as well as synaptic proteins (growth-associated protein 43 [GAP43], synaptophysin [SYP], post-synaptic density 95 [PSD95] and microtubule-associated protein 2 [MAP2]) were significantly higher in the Tg-NSCs-ev group, when compared with the Tg-Veh group. In addition, oxidative damage markers (anti-4...Continue Reading

References

May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Apr 12, 2003·Progress in Lipid Research·Koji Uchida
Aug 4, 2004·Free Radical Biology & Medicine·Yogesh C AwasthiSanjay Awasthi
Sep 27, 2005·The Journal of Biological Chemistry·Jennifer ChenLi Gan
Dec 28, 2005·Neurobiology of Disease·Rukhsana SultanaD Allan Butterfield
Jul 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lawrence RajendranKai Simons
Jul 11, 2007·Current Opinion in Neurology·Agneta Nordberg
Jan 30, 2008·Current Protocols in Cell Biology·Clotilde ThéryAled Clayton
Jul 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ron BrookmeyerH Michael Arrighi
Jan 31, 2012·Seminars in Cell & Developmental Biology·Geoffrey D Girnun
Feb 4, 2012·The Journal of Biological Chemistry·Kohei YuyamaYasuyuki Igarashi
Feb 22, 2012·Advances in Experimental Medicine and Biology·Elena MarcelloMonica Di Luca
Jun 19, 2012·The Biochemical Journal·David CarlingMatthew J Sanders
Dec 4, 2012·Free Radical Biology & Medicine·Michael H YanXiongwei Zhu
Dec 20, 2012·International Journal of Alzheimer's Disease·Gizem Donmez
Apr 16, 2013·Nature Reviews. Drug Discovery·Samir EL AndaloussiMatthew J A Wood
Apr 17, 2014·Biochemical and Biophysical Research Communications·Qinru SunNing Jia
May 31, 2014·Biochimica Et Biophysica Acta·Gurdeep MarwarhaOthman Ghribi
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Marina ColomboClotilde Théry
Dec 1, 2010·NDT Plus·Marijn M SpeeckaertJoris R Delanghe
Apr 8, 2016·Cellular and Molecular Neurobiology·Erik R Abels, Xandra O Breakefield

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Citations

May 8, 2020·Mediators of Inflammation·Jingxuan SunWei Wang
Oct 25, 2020·Bulletin of Experimental Biology and Medicine·A E PukhalskaiaI M Kvetnoy
Nov 26, 2020·International Journal of Molecular Sciences·Morris Losurdo, Mariagrazia Grilli
Dec 1, 2020·Frontiers in Cellular Neuroscience·Cory M WillisStefano Pluchino
Mar 7, 2021·International Journal of Molecular Sciences·José A Fernández-AlbarralAna I Ramírez
Mar 8, 2021·Alzheimer's Research & Therapy·Lauren A ApodacaJanet E Baulch
Mar 22, 2021·Molecular Neurobiology·Nashmin FayaziRezvan Najafi
Apr 4, 2021·International Journal of Molecular Sciences·Sean T RyanJiao Jiao Li
Apr 4, 2021·International Journal of Molecular Sciences·Mehdi EshraghiSaeid Ghavami
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Ping YuanJialin C Zheng
Jul 17, 2021·Neurobiology of Disease·Samantha L Reed, Andrew Escayg

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