Impact of neurological diseases on the prognosis of bullous pemphigoid: A retrospective study of 178 patients

Annales de dermatologie et de vénéréologie
V ChevalierP Bernard

Abstract

Bullous pemphigoid (BP) mainly affects elderly patients. It is often associated with neurological disorders, which constitute a major risk factor of the disease. The aim of our study was to determine whether neurological disorders, particularly dementia, influence outcome and mortality in BP patients. We conducted a retrospective study of all patients with BP seen in our dermatology department consecutively between 1997 and 2011. Clinical, immunological and therapeutic data, number of relapses and survival status were compared according to the presence at diagnosis of neurological disorders, particularly dementia. Among the 178 patients included, an associated neurological disease was present in 84 (47.2%) and dementia in 43 (24.2%) at the time of diagnosis of BP. Patients with associated dementia were older and had a lower Karnofsky index. Sixty-four patients (37.8%) had had at least one clinical relapse of BP, chiefly within the first 18 months after starting therapy. Coexistent neurological disease was not associated with BP relapse (P=0.55) contrary to an extensive BP phenotype at diagnosis (P=0.008). Coexistent neurological disease and/or dementia were associated with higher mortality (P=0.03 and P<0.001, respectively), bu...Continue Reading

References

Nov 1, 1995·Clinical and Experimental Dermatology·G KirtschigF Wojnarowska
Feb 1, 2002·The New England Journal of Medicine·Pascal JolyUNKNOWN Bullous Diseases French Study Group
Mar 25, 2005·The British Journal of Dermatology·E LaffitteL Borradori
Apr 13, 2005·Acta Dermato-venereologica·Giuseppe StincoPasquale Patrone
Sep 8, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Nadège CordelUNKNOWN French Study Group of Bullous Diseases
Oct 15, 2010·The Journal of Investigative Dermatology·Sylvie Bastuji-GarinUNKNOWN French Study Group for Bullous Diseases
Nov 19, 2010·The Journal of Investigative Dermatology·Sinéad M LanganJoe West
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Mar 16, 2012·The Journal of Investigative Dermatology·Pascal JolyJacques Bénichou
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Sep 2, 2014·Journal of the American Academy of Dermatology·Katherine E BrickCarilyn N Wieland

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Citations

Mar 2, 2017·American Journal of Clinical Dermatology·Philippe Bernard, Frank Antonicelli
Apr 3, 2018·The British Journal of Dermatology·M M HoltscheUNKNOWN members of the BLISTER Study Group
Aug 6, 2017·Clinical Reviews in Allergy & Immunology·Kyle T AmberLuca Borradori
Sep 5, 2018·Frontiers in Medicine·Khalaf Kridin, Ralf J Ludwig
Jun 21, 2017·International Scholarly Research Notices·Sheida KhosravaniNasrin Saki

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