Impact of new DAA therapy on real clinical practice: a multicenter region-wide cohort study

BMC Infectious Diseases
Simone Laninimembers of the Lazio Region HCV treatment group

Abstract

Management of chronic hepatitis C (CHC) has significantly accelerated in the last few years. Currently, second generation direct acting antivirals (DAAs) promise clearance of infection in most of patients. Here we present the results of the first analysis carried out on data of Lazio clinical network for DAAs. The study was designed as a multicenter cohort: a) to assess the evolution of treatment during the first 24 months of the activity of the Clinical Network; b) to report overall efficacy of treatments; c) to analyze potential factors associated with lack of virological response at 12 weeks after therapy (SVR12); d) to evaluate the variation of ALT at baseline and 12 weeks after therapy in those who achieved SVR12 in comparison to those who did not. Analyses of efficacy were carried out with multilevel mixed effect logistic regression model. ALT temporal variation was assessed by mixed effect model mixed models with random intercept at patient's level and random slope at the level of the time; i.e. either before or after therapy. Between 30 December 2014 and 31 December 2016 5279 patients started a DAA treatment; of those, 5127 (in 14 clinical centers) had completed the 12-week follow-up. Overall proportion of SVR12 was 93....Continue Reading

References

Jul 16, 2011·Journal of Hepatology·Jennifer R KramerHashem B El-Serag
Aug 2, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jian-Wu YuBing-Zhu Yan
Apr 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Natasha K MartinMatthew Hickman
Sep 25, 2014·International Journal of Antimicrobial Agents·Giuseppe IppolitoGuido Antonelli
Jan 15, 2015·BMJ : British Medical Journal·Ronald L KoretzJeanne Lenzer
Apr 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Rajender ReddyNezam Afdhal
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Jul 4, 2015·World Journal of Hepatology·Lourianne Nascimento Cavalcante, André Castro Lyra
Nov 10, 2015·The Journal of Clinical Investigation·Simone LaniniUNKNOWN INMI-EMERGENCY EBOV Sierra Leone Study Group
Jan 13, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fred PoordadEugene S Swenson
Apr 27, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lisa I BackusLarry A Mole
Aug 16, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S LaniniG Ippolito
Oct 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick IngilizStefan Mauss
Sep 27, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Marcus M MückeStefan Zeuzem
Feb 9, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carlos Fernández CarrilloJosé Luis Calleja
Feb 13, 2017·Journal of Hepatology·Jose Luis CallejaUNKNOWN Spanish Group for the Study of the Use of Direct-acting Drugs Hepatitis C Collaborating Group
Mar 21, 2017·Annals of Internal Medicine·Oluwaseun Falade-NwuliaMark S Sulkowski
May 10, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Zoe MariñoXavier Forns
May 16, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Varun SaxenaK Rajender Reddy
May 19, 2017·PloS One·Antonella d'Arminio MonforteUNKNOWN Icona Foundation and HepaIcona Study Group
May 23, 2017·Lancet·UNKNOWN GBD 2015 Healthcare Access and Quality Collaborators. Electronic address: cjlm@uw.edu, UNKNOWN GBD 2015 Healthcare Access and Quality Collaborators
Jul 8, 2017·BMJ : British Medical Journal·Jawad Ahmad
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Simone LaniniUNKNOWN INMI-EMERGENCY EBOV Sierra Leone Study Group
Jan 13, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G IppolitoS Lanini
Jan 30, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan BerenguerJuan J González-García

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Citations

Sep 16, 2018·BMC Infectious Diseases·Emily AdlandPhilippa C Matthews
Oct 17, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·G IrelandS Mandal
Sep 10, 2020·Microbiology and Immunology·Mandana NamayandehMazyar Ziyaeyan
Dec 1, 2020·European Journal of Gastroenterology & Hepatology·David Rial-CresteloUNKNOWN Grupo de Estudio de Castilla la Manche de enfermedades Infecciosas (GECMEI)
Jan 6, 2021·The American Journal of Gastroenterology·Jia LiUNKNOWN CHeCS Investigators
Jun 21, 2020·Gastroenterología y hepatología·José CastelloteMaría Buti
Jun 21, 2020·Gastroenterología y hepatología·Emilio Monte-BoquetPere Ventayol
Nov 14, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julieta PolitiEnrique Regidor

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