Impact of nitric-oxide-mediated vasodilation and oxidative stress on renal medullary oxygenation: a modeling study

American Journal of Physiology. Renal Physiology
Brendan C FryAnita T Layton

Abstract

The goal of this study was to investigate the effects of nitric oxide (NO)-mediated vasodilation in preventing medullary hypoxia, as well as the likely pathways by which superoxide (O2(-)) conversely enhances medullary hypoxia. To do so, we expanded a previously developed mathematical model of solute transport in the renal medulla that accounts for the reciprocal interactions among oxygen (O2), NO, and O2(-) to include the vasoactive effects of NO on medullary descending vasa recta. The model represents the radial organization of the vessels and tubules, centered around vascular bundles in the outer medulla and collecting ducts in the inner medulla. Model simulations suggest that NO helps to prevent medullary hypoxia both by inducing vasodilation of the descending vasa recta (thus increasing O2 supply) and by reducing the active sodium transport rate (thus reducing O2 consumption). That is, the vasodilative properties of NO significantly contribute to maintaining sufficient medullary oxygenation. The model further predicts that a reduction in tubular transport efficiency (i.e., the ratio of active sodium transport per O2 consumption) is the main factor by which increased O2(-) levels lead to hypoxia, whereas hyperfiltration is ...Continue Reading

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Citations

Mar 31, 2017·American Journal of Physiology. Renal Physiology·Ying ChenAnita T Layton
Dec 20, 2018·American Journal of Physiology. Renal Physiology·Anita T Layton, Jennifer C Sullivan
Jan 20, 2017·American Journal of Physiology. Renal Physiology·Anita T Layton
Feb 6, 2020·Acta Physiologica·Bruce S GardinerRoger G Evans
Jul 3, 2016·Bulletin of Mathematical Biology·Ying ChenAnita T Layton
Aug 4, 2020·American Journal of Physiology. Renal Physiology·Rui HuAnita T Layton
Jun 30, 2018·Biological cybernetics·Anita T Layton
Jul 18, 2019·American Journal of Physiology. Renal Physiology·Anita T Layton
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Dec 4, 2019·American Journal of Physiology. Renal Physiology·Aurélie EdwardsAnita T Layton
Oct 1, 2019·American Journal of Physiology. Renal Physiology·Rui HuAnita T Layton
Mar 7, 2021·International Journal of Molecular Sciences·Pauline ChazelasJérôme Guillard
May 13, 2017·Mathematical Biosciences·Ying ChenAnita T Layton
Jan 25, 2020·Mathematical Biosciences·Marta MarulliNicolas Vauchelet

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