Impact of nocturnal heart rate variability on cerebral small-vessel disease progression: a longitudinal study in community-dwelling elderly Japanese

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yoshitaka YamaguchiTakeo Kato

Abstract

Recent evidence has shown an effect of ambulatory heart rate (HR) on cardiovascular events and mortality. Our objective was to determine whether ambulatory HR was related to the progression of cerebral small-vessel disease (SVD) or cognitive decline in community-dwelling elderly people. A cohort of 190 community-dwelling elderly people underwent an ambulatory blood pressure monitoring (ABPM), brain magnetic resonance imaging (MRI) and cognitive testing at baseline, with MRI and cognitive tests repeated 4 years later. HR variability in ABPM was quantified by the s.d. (s.d. and the root mean square of successive differences (RMSSD), and the relationship between HR variability and the progression of SVD/cognitive decline was investigated. We also assessed the association of nighttime HR variability and nocturnal HR dipping. The nighttime RMSSD of participants with the progression of SVD was significantly higher than that of those without progression of SVD (P<0.05). Moreover, nighttime RMSSD was independently associated with the progression of SVD (1 b.p.m. increment: odds ratio=1.13, 95% confidence interval=1.04-1.24, P<0.01). We failed to confirm an association between cognitive decline and nighttime HR variability. However, s.d...Continue Reading

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Citations

Jan 8, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Lei WuYiyan Wang
Mar 18, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Francesca SantilliGiovanni Davì
Mar 25, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hirochika RyunoHiromi Rakugi
Nov 25, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Stefano OmboniAnatoly N Rogoza
Feb 17, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomoko YoshikawaYoshitaka Hirooka
Feb 17, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Marios K GeorgakisEleni Th Petridou
Oct 20, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Oscar H Del BruttoErnesto Peñaherrera
Apr 17, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuichiro Yano
Jul 28, 2019·Stroke; a Journal of Cerebral Circulation·Oscar H Del BruttoPablo R Castillo
Oct 6, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Haruhito A UchidaJun Wada
Feb 26, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yang-Kun ChenJian-Feng Qu
Jul 2, 2021·The Journal of Clinical Hypertension·Danyang TianDongsheng Fan

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