Impact of non-CNS childhood cancer on resting-state connectivity and its association with cognition.

Brain and Behavior
Janine S SpitzhüttlRegula Everts

Abstract

Non-central nervous system cancer in childhood (non-CNS CC) and its treatments pose a major threat to brain development, with implications for functional networks. Structural and functional alterations might underlie the cognitive late-effects identified in survivors of non-CNS CC. The present study evaluated resting-state functional networks and their associations with cognition in a mixed sample of non-CNS CC survivors (i.e., leukemia, lymphoma, and other non-CNS solid tumors). Forty-three patients (off-therapy for at least 1 year and aged 7-16 years) were compared with 43 healthy controls matched for age and sex. High-resolution T1-weighted structural magnetic resonance and resting-state functional magnetic resonance imaging were acquired. Executive functions, attention, processing speed, and memory were assessed outside the scanner. Cognitive performance was within the normal range for both groups; however, patients after CNS-directed therapy showed lower executive functions than controls. Seed-based connectivity analyses revealed that patients exhibited stronger functional connectivity between fronto- and temporo-parietal pathways and weaker connectivity between parietal-cerebellar and temporal-occipital pathways in the ri...Continue Reading

References

Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Jan 4, 2003·Nature Reviews. Neuroscience·Arthur W Toga, Paul M Thompson
Jan 28, 2003·Nature Neuroscience·Elizabeth R SowellArthur W Toga
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nitin GogtayPaul M Thompson
Dec 22, 2004·Journal of Pediatric Psychology·Bartlett D Moore
Apr 16, 2005·Current Opinion in Neurobiology·B J CaseyTodd A Hare
Jan 11, 2008·AJNR. American Journal of Neuroradiology·M E CareyK L Kaemingk
Jun 12, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den HeuvelHilleke E Hulshoff Pol
Dec 3, 2009·Pediatric Blood & Cancer·Kristen E RobinsonBruce E Compas
Apr 22, 2010·Frontiers in Systems Neuroscience·David M ColeChristian F Beckmann
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon B EickhoffTimothy E J Behrens
Sep 4, 2010·Brain Imaging and Behavior·Shelli R KeslerDella Koovakkattu
Apr 9, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·F G HillaryG R Wylie
May 31, 2012·Brain Connectivity·Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon
Jun 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael W ColeTodd S Braver
Sep 1, 2012·AJNR. American Journal of Neuroradiology·M H LeeJ S Shimony
Nov 16, 2013·Trends in Cognitive Sciences·Martijn P van den Heuvel, Olaf Sporns
Jan 17, 2014·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Karin S WalshPim Brouwers
Mar 13, 2014·Pediatric Blood & Cancer·Shelli R KeslerNorman Lacayo
Aug 16, 2014·Brain : a Journal of Neurology·Michelle N EdelmannWilburn E Reddick
Nov 22, 2014·AJNR. American Journal of Neuroradiology·F D RaslauL P Mark
Jun 24, 2015·Journal of the National Cancer Institute·Sunita K PatelSmita Bhatia
Mar 1, 2014·Wiley Interdisciplinary Reviews. Cognitive Science·W Dale Stevens, R Nathan Spreng
Apr 24, 2016·The Annals of Thoracic Surgery·Andrew D Althouse
Oct 12, 2017·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Ellen Van Der PlasBrenda J Spiegler
Mar 8, 2018·Journal of the National Cancer Institute·Thibo BillietSabine Deprez
Jun 7, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin R KrullShelli R Kesler

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Citations

Nov 20, 2020·Neuropsychological Rehabilitation·Valerie SiegwartRegula Everts

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

Statistical Package for Social Sciences ( SPSS )
MATLAB
fMRI
CONN
SPM12
Statistic T
AFNI
CAT12
CompCor
Brainfit

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