Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease

Journal of the American Heart Association
Qianyi WangGlobal Burden of Diseases Nutrition and Chronic Diseases Expert Group (NutriCoDE)

Abstract

Saturated fat (SFA), ω-6 (n-6) polyunsaturated fat (PUFA), and trans fat (TFA) influence risk of coronary heart disease (CHD), but attributable CHD mortalities by country, age, sex, and time are unclear. National intakes of SFA, n-6 PUFA, and TFA were estimated using a Bayesian hierarchical model based on country-specific dietary surveys; food availability data; and, for TFA, industry reports on fats/oils and packaged foods. Etiologic effects of dietary fats on CHD mortality were derived from meta-analyses of prospective cohorts and CHD mortality rates from the 2010 Global Burden of Diseases study. Absolute and proportional attributable CHD mortality were computed using a comparative risk assessment framework. In 2010, nonoptimal intakes of n-6 PUFA, SFA, and TFA were estimated to result in 711 800 (95% uncertainty interval [UI] 680 700-745 000), 250 900 (95% UI 236 900-265 800), and 537 200 (95% UI 517 600-557 000) CHD deaths per year worldwide, accounting for 10.3% (95% UI 9.9%-10.6%), 3.6%, (95% UI 3.5%-3.6%) and 7.7% (95% UI 7.6%-7.9%) of global CHD mortality. Tropical oil-consuming countries were estimated to have the highest proportional n-6 PUFA- and SFA-attributable CHD mortality, whereas Egypt, Pakistan, and Canada wer...Continue Reading

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Citations

Sep 1, 2016·Journal of Clinical Lipidology·Michael MillerAndrew P Goldberg
Dec 28, 2016·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Chikako Uneyama, Miou Toda
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May 25, 2021·Current Developments in Nutrition·Chaoyang LiHubert W Vesper
Aug 17, 2021·Public Health Nutrition·Madalyn QuinnJennifer Lacy-Nichols

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Software Mentioned

NutriCoDE
R
R Foundation for Statistical Computing

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