PMID: 11604335Oct 18, 2001Paper

Impact of nonpenetrating clips on intimal hyperplasia of vascular anastomoses

Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery
S S BermanY Chai

Abstract

Non-penetrating, arcuate-legged titanium clips create an interrupted, non-penetrated, yet compliant vascular anastomoses that is associated with significantly reduced anastomotic neointimal hyperplasia. Recent experimental and clinical studies provide evidence that the non-suture alternative changes the biology of vessel-to-vessel and graft-to-vessel connections that reduces the stimulus for hyperplasia at a number of critical points in the response to injury schema. The compliant, "blood-tight" characteristics of clipped vascular reconstructions are associated with no endothelial injury or intraluminal foreign body, minimal platelet aggregation and laminal flow. Clinical applications including vascular access, femoropopliteal bypass, and closure of carotid endarterectomies are remarkable for the absence of restenosis and preserved anastomotic patency.

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Citations

Jul 20, 2002·Journal of Biomechanics·Quentin GrimalSalah Naili
Nov 2, 2007·Theoretical Biology & Medical Modelling·Vladimir M Subbotin
Nov 4, 2008·Spine·Jing YuanSuzanne McDonough
Jun 12, 2004·American Journal of Surgery·Clark J ZeebregtsReinout van Schilfgaarde
Feb 21, 2003·The British Journal of Surgery·C J ZeebregtsR van Schilfgaarde

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