Impact of nutritional supplementation during pregnancy on antibody responses to diphtheria-tetanus-pertussis vaccination in infants: A randomised trial in The Gambia.

PLoS Medicine
Sandra G OkalaSophie E Moore

Abstract

Exposure to a nutritionally deficient environment during fetal life and early infancy may adversely alter the ontogeny of the immune system and affect an infant's ability to mount an optimal immune response to vaccination. We examined the effects of maternal nutritional supplementation during pregnancy on infants' antibody responses to the diphtheria-tetanus-pertussis (DTP) vaccine included in the Expanded Programme on Immunisation (EPI). The Early Nutrition and Immune Development (ENID) trial was a randomised, partially blinded trial conducted between April 2010 and February 2015 in the rural West Kiang region of The Gambia, a resource-poor region affected by chronic undernutrition. Pregnant women (<20 weeks' gestation) with a singleton pregnancy (n = 875) were randomised to receive one of four supplements: iron-folic acid (FeFol; standard of care), multiple micronutrient (MMN), protein-energy (PE), or PE + MMN daily from enrolment (mean [SD] 13.7 [3.3] weeks' gestation) until delivery. Infants were administered the DTP vaccine at 8, 12, and 16 weeks of age according to the Gambian Government protocol. Results for the primary outcome of the trial (infant thymic size) were described previously; here, we report on a secondary ou...Continue Reading

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Citations

Aug 28, 2019·PLoS Medicine·Lars Åke PerssonHuixia Yang
Aug 28, 2020·Frontiers in Microbiology·Anja Saso, Beate Kampmann
Mar 31, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mícheál Ó BreasailAnn Prentice

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Methods Mentioned

BETA
ELISA
antibody assay

Clinical Trials Mentioned

ISRCTN49285450

Software Mentioned

Bio
STATA
plex Manager

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