Impact of obesity on left ventricular systolic function in hypertensive subjects with normal ejection fraction

International Journal of Cardiology
Piercarlo BalloSergio Mondillo

Abstract

We sought to investigate the potential impact of obesity on left ventricular (LV) systolic function in patients with hypertension and normal ejection fraction (EF). In 112 hypertensive subjects with echocardiographic evidence of normal EF, M-mode left atrio-ventricular plane displacement, and Tissue Doppler-derived peak systolic velocity of the mitral annulus were measured and used as sensitive indices of longitudinal LV systolic dysfunction. The midwall stress-shortening relation was considered as a sensitive load-independent measure of circumferential LV myocardial contractility. There were no differences in either atrio-ventricular plane displacement or peak systolic velocity between normal weight, overweight, and obese subjects. In contrast, circumferential myocardial contractility tended to be reduced in overweight (90.3+/-14.4%) and was significantly depressed in obese (85.9+/-14.3%) as compared to normal weight individuals (95.3+/-14.8%; P=0.042). Multivariate analysis confirmed an independent negative association between body mass index (BMI) and myocardial contractility. The impact of BMI category on circumferential function did not differ between the study population and age- and gender-matched controls, suggesting ad...Continue Reading

References

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Aug 2, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Vitantonio Di BelloAldo Pinchera
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Citations

Jan 14, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Massimo LeggioAnna Patrizia Jesi
Dec 24, 2013·Journal of Cardiac Failure·Piercarlo BalloUNKNOWN Working Group Nucleus on Echocardiography of the Italian Society of Cardiology
Jan 21, 2014·Progress in Cardiovascular Diseases·Martin A AlpertSivakumar Ardhanari
Mar 5, 2014·Clinical Physiology and Functional Imaging·Soraia P JürgensenAudrey Borghi-Silva
May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang

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