Impact of obstructive and central apneas on ventricular repolarisation: lessons learned from studies in man and pigs

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Dominik LinzMichael Böhm

Abstract

Sleep apnea (SA) is associated with sudden cardiac death. Compared to central apneas, obstructive apneas are associated with negative intrathoracic pressure swings inducing autonomic imbalance, which may disturb ventricular repolarisation resulting in arrhythmias. To identify the influence of obstructive apneas versus central apneas on ventricular repolarisation. In 14 patients with SA, duration (RT-intervals) and dispersion of ventricular repolarisation [Tpeak-to-Tend-interval (TpTe)] were determined during central apneas compared to obstructive apneas. To identify mechanisms, hypoxia alone or hypoxia with applied negative thoracic pressure was applied in a pig model for SA before and after atropine (n = 7), atenolol (n = 5) and sympathetic renal denervation (RDN, n = 7). In patients with SA, obstructive apneas during sleep were always associated with a prolongation of RT- as well as TpTe intervals. By contrast central apneas did not affect ventricular repolarisation significantly in the same patients. In the pig model for SA, 2 min of acute tracheal occlusion with applied negative thoracic pressure resulted in a prolongation in RT- and TpTe-interval. These changes in ventricular repolarisation could be inhibited by atenolol a...Continue Reading

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Citations

Feb 14, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Dominik LinzOlaf Oldenburg
Feb 13, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Dominik LinzMichael Böhm
Oct 20, 2018·Current Cardiology Reviews·Rita MarinheiroRui Caria
Sep 25, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Johanna StrotmannOlaf Oldenburg
Oct 30, 2019·European Journal of Preventive Cardiology·Jens SpiesshoeferOlaf On Behalf Of The German Cardiac Society Working Group On Sleep Disordered Breathing Ag-Deutsche Gesellschaft Für Kardiologie
Aug 10, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Insa E EmrichGunnar H Heine
Dec 24, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kathrin WeidnerIbrahim Akin
May 19, 2019·International Journal of Molecular Sciences·Márcio Galindo KiuchiMarkus P Schlaich
May 10, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Hazem OmranHenrik Fox
Apr 29, 2020·Journal of Forensic and Legal Medicine·Domyung Paek, Dae-Ik Kwon
Mar 17, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Benedikt LinzThomas Jespersen
Aug 7, 2021·Journal of the American College of Cardiology·Martin R CowieAnita K Simonds

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