Impact of old age on resectable colorectal cancer outcomes

PeerJ
Jianfei FuJinlin Du

Abstract

This study was performed to identify a reasonable cutoff age for defining older patients with colorectal cancer (CRC) and to examine whether old age was related with increased colorectal cancer-specific death (CSD) and poor colorectal cancer-specific survival (CSS). A total of 76,858 eligible patients from the surveillance, epidemiology, and end results (SEER) database were included in this study. The Cox proportional hazard regression model and the Chow test were used to determine a suitable cutoff age for defining the older group. Furthermore, a propensity score matching analysis was performed to adjust for heterogeneity between groups. A competing risk regression model was used to explore the impact of age on CSD and non-colorectal cancer-specific death (non-CSD). Kaplan-Meier survival curves were plotted to compare CSS between groups. Also, a Cox regression model was used to validate the results. External validation was performed on data from 1998 to 2003 retrieved from the SEER database. Based on a cutoff age of 70 years, the examined cohort of patients was classified into a younger group (n = 51,915, <70 years of old) and an older group (n = 24,943, ≥70 years of old). Compared with younger patients, older patients were mo...Continue Reading

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Citations

Dec 20, 2019·Dose-response : a Publication of International Hormesis Society·Zhi HuangSha-Sha Peng

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

strucchange
Matchit
ACCENT
R Core Team
R
SEER
Stat

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