Impact of oral melatonin on the electroretinogram cone response.

Journal of Circadian Rhythms
Anne-Marie GagnéM Hébert

Abstract

In the eye, melatonin plays a role in promoting light sensitivity at night and modulating many aspects of circadian retinal physiology. It is also an inhibitor of retinal dopamine, which is a promoter of day vision through the cone system. Consequently, it is possible that oral melatonin (an inhibitor of retinal dopamine) taken to alleviate circadian disorders may affect cone functioning. Our aim was to assess the impact of melatonin on the cone response of the human retina using electroretinography (ERG). Twelve healthy participants aged between 18 to 52 years old were submitted to a placebo-controlled, double-blind, crossover, and counterbalanced-order design. The subjects were tested on 2 sessions beginning first with a baseline ERG, followed by the administration of the placebo or melatonin condition and then, 30 min later, a second ERG to test the effect. Following oral melatonin administration, a significant decrease of about 8% of the cone maximal response was observed (mean 6.9 muV +/- SEM 2.0; P = 0.0065) along with a prolonged b-wave implicit time of 0.4 ms +/- 0.1, 50 minutes after ingestion. Oral melatonin appears to reach the eye through the circulation. When it is administered at a time of day when it is not usual...Continue Reading

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Citations

Feb 12, 2010·Documenta Ophthalmologica. Advances in Ophthalmology·J LavoieM Hébert
Oct 26, 2013·Frontiers in Neuroendocrinology·Vincent M Cassone
Jul 5, 2011·Chronobiology International·Konstantin V DanilenkoMarc Hébert
Sep 11, 2012·Experimental Eye Research·Gianluca TosiniP Michael Iuvone
Apr 9, 2013·Neuroscience Letters·Joëlle LavoieMarc Hébert
Jun 21, 2018·Journal of Neural Engineering·Antje KiliasPolina Anikeeva
Oct 3, 2018·The European Journal of Neuroscience·Gladys Y-P Ko
Apr 15, 2020·Journal of Neural Engineering·Nikolai SmetaninAlexei Ossadtchi
Mar 10, 2020·Neuroscience and Biobehavioral Reviews·Eve CoskerThomas Schwitzer

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