Impact of overlapping drug-eluting stents in patients undergoing percutaneous coronary intervention

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
William W ChuRon Waksman

Abstract

Sirolimus-eluting stent (SES) implantation for the treatment of single coronary lesions is proven to be effective and durable. However, the safety and efficacy of overlapping SES for the treatment of long lesions have not been well established. We conducted a retrospective analysis to compare the clinical outcomes of overlapping versus nonoverlapping SES. Fifty-five patients who received overlapping SES were compared with 39 patients who received nonoverlapping SES. The baseline clinical and angiographic characteristics were balanced between the two study groups. The in-hospital complications were similar between groups, except that non-Q-wave myocardial infarction was significantly higher in the Overlapping SES group when compared with the Nonoverlapping SES group (23.6% vs. 7.7%, P = 0.04). This higher rate of myonecrosis is due to periprocedural side branch compromises, including side branch narrowing, occlusion, and flow reduction. At 30 days and 6 months follow-up, all clinical outcomes were similar between the study groups. In addition, the event-free survival rate was similar between groups (P = 0.87). The implantation of overlapping SES for the treatment of long, native coronary lesions is feasible and effective but is ...Continue Reading

References

Jul 7, 1999·The American Journal of Cardiology·A KastratiA Schömig
Jun 7, 2002·The New England Journal of Medicine·Marie-Claude MoriceUNKNOWN RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patie
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Jan 16, 2004·The New England Journal of Medicine·Gregg W StoneUNKNOWN TAXUS-IV Investigators
Mar 31, 2004·The American Journal of Cardiology·Muzaffer DegertekinPatrick W Serruys
Jun 30, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sang Hak LeeGil Jin Jang
Oct 11, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Michael SchlüterJoachim Schofer

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Citations

Oct 15, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Helge MöllmannAlbrecht Elsässer
Nov 26, 2008·International Journal of Cardiology·Giampaolo NiccoliFilippo Crea
Jun 4, 2010·Asian Cardiovascular & Thoracic Annals·Chi-Hang LeeHuay-Cheem Tan
Dec 2, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Simon J CorbettAntonio Colombo
Aug 25, 2010·Clinical Cardiology·Elias B Hanna, Thomas A Hennebry
Aug 30, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Takenori OkadaNobuoki Kohno
Jan 30, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Qi ZhangRui Yan Zhang

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