Impact of Oxidative Stress and Newer Antiepileptic Drugs on the Albumin and Cortisol Value in Severe Motor and Intellectual Disabilities With Epilepsy

Journal of Clinical Medicine Research
Masahito MorimotoShojiro Kyotani

Abstract

Epilepsy is a common complication in patients with severe motor and intellectual disabilities (SMID). There are no reports as yet of the effects of these medications in vivo other than their epileptic efficacy. The purpose of this study was to clarify the effects of the newer antiepileptic drugs (AEDs) on the blood biochemical parameters and oxidative stress in SMID with epilepsy by comparing the therapeutic effects between a group of patients receiving lamotrigine (LTG) and levetiracetam (LEV) in addition to the conventional AEDs (newer AED group) and a group receiving conventional AEDs alone (old AED group). The study population consisted of 44 SMID patients with epilepsy, of which 23 were allocated to the newer AED group and 21 were allocated to the old AED group. In the newer AED group, measurements of the reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP) and serum albumin were carried out at the following two time points: 1 week before and 1 year after the start of administration of the newer AEDs. In the old AED group, measurements of the same variables were performed at two time points 1 year apart. A significant decrease of the d-ROM levels and a significant increase of the BAP were noted in t...Continue Reading

Citations

Jun 4, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Achilleas AttilakosAnastasia Garoufi
Mar 21, 2020·Frontiers in Psychiatry·Adrián Alacreu-CrespoPhilippe Courtet
Apr 18, 2018·Dose-response : a Publication of International Hormesis Society·Tahereh FarkhondehFariborz Samini
Mar 14, 2019·Behavioural Neurology·Ebrahim M YimerAbadi Kahsu Gebre
Mar 24, 2020·Epilepsy & Behavior : E&B·Ayataka FujimotoHideo Enoki

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