Impact of oxidative stress on neuronal survival

Clinical and Experimental Pharmacology & Physiology
Juliet M Taylor, Peter J Crack

Abstract

1. Reactive oxygen species and oxidative state are slowly gaining acceptance in having a physiological relevance rather than just being the culprits in pathophysiological processes. The control of the redox environment of the cell provides for additional regulation in relation to signal transduction pathways. Conversely, aberrant regulation of oxidative state manifesting as oxidative stress can predispose a cell to adverse outcome. 2. The phosphatidylinositol 3-kinase/akt pathway is one such pathway that is partially regulated via oxidative state and, in an oxidative stress paradigm such as ischaemic-reperfusion injury, may be inactivated, which can lead to exacerbation of cell death. 3. Activation of nuclear factor (NF)-kappaB has been associated with oxidative stress. The role of NF-kappaB in neuronal cell death is widely debated, with major studies highlighting both a pro- and anti-apoptotic role for NF-kappaB, with the outcome being region, stimulus, dose and duration specific. 4. Oxidative state plays a key role in the regulation and control of numerous signal transduction pathways in the cell. Elucidating the mechanisms behind oxidative stress-mediated neuronal cell death is important in identifying potential putative tar...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KinouchiP H Chan
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R C CrumrineP F Morgan
Jun 1, 1994·Molecular and Cellular Biology·C KaltschmidtP A Baeuerle
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Z HuangM A Moskowitz
Jan 1, 1997·Free Radical Biology & Medicine·L FlohéL Packer
Mar 1, 1997·Neuroscience and Biobehavioral Reviews·M P Mattson
May 1, 1997·Stroke; a Journal of Cerebral Circulation·J A ClemensS P Little
Sep 26, 1997·Stroke; a Journal of Cerebral Circulation·K MurakamiP H Chan
Apr 29, 1998·Brain Research. Molecular Brain Research·M Weisbrot-LefkowitzO Mirochnitchenko
Apr 30, 1998·Current Opinion in Cell Biology·T Finkel
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·C BéraudP A Baeuerle
Feb 26, 1999·Brain Research. Molecular Brain Research·C GabrielA M Planas
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·T S DoiY Obata
May 6, 1999·Nature Medicine·A SchneiderM Schwaninger
Jun 9, 1999·Current Biology : CB·L P KaneA Weiss
Sep 15, 1999·Nature·A Khwaja
Sep 15, 1999·Nature·J A Romashkova, S S Makarov
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Dec 14, 1999·Journal of Neurotrauma·M NonakaD H Smith
Jan 19, 2000·Experimental Brain Research·B Kaltschmidt, C Kaltschmidt
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S A ReddyW S Liao
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D StephensonJ Clemens
Feb 13, 2001·The Journal of Clinical Investigation·M P Mattson, S Camandola
Feb 13, 2001·Neurobiology of Disease·S JanelidzeB K Siesjö
Feb 15, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C Y HuangP H Chan
Apr 26, 2001·Apoptosis : an International Journal on Programmed Cell Death·M P MattsonC Culmsee

❮ Previous
Next ❯

Citations

Aug 1, 2007·Experimental Brain Research·Sheikh Arshad SaeedMuhammad Umair Khan
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Kundan Singh Bora, Anupam Sharma
Jun 2, 2012·Clinical and Experimental Pharmacology & Physiology·Yan-Ting ChenYun Xu
Feb 5, 2013·International Journal of Nanomedicine·Manal Fouad IsmailNeveen Abdel-Hameed Salem
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Zhihong LinKefeng Ruan
May 4, 2010·Journal of Ethnopharmacology·Kundan Singh Bora, Anupam Sharma
Jun 13, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ravindra M SatputeHatim F Daginawala
Mar 8, 2016·Journal of Plastic Surgery and Hand Surgery·Burak ErsoyÖzlem Tuğçe Çilingir
Jan 7, 2010·Journal of Neurochemistry·Chao LiuJianguo Chen
Jan 31, 2006·Free Radical Biology & Medicine·Rao Muralikrishna Adibhatla, J F Hatcher
Aug 30, 2008·BMB Reports·Rao Muralikrishna Adibhatla, J F Hatcher
Mar 8, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo ZhaoLian-Jun Guo
Jul 21, 2005·In Vitro Cellular & Developmental Biology. Animal·Kimberly C WiseGovindarajan T Ramesh
Oct 28, 2005·Journal of Neural Transmission·P J CrackR C Iannello
Aug 2, 2017·The American Journal of Chinese Medicine·Jing LiZuo-Hui Shao
Nov 30, 2006·Clinical Science·Jan P KonsmanAnne-Marie Van Dam
Oct 11, 2021·Biology of Sex Differences·Karen R BottenfieldTara L Moore

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.