PMID: 8969395Dec 1, 1996Paper

Impact of oxygenator design on hemolysis, shear stress, and white blood cell and platelet counts

Journal of Cardiothoracic and Vascular Anesthesia
D De SomerG Van Nooten

Abstract

To determine whether relative pressure drop, shear stress, hemolysis, and white blood cell and platelet counts are influenced by different oxygenator designs. To compare the oxygenator results with the average shear stress over an arterial cannula. Prospective; patients enrolled consecutively. University hospital. Three groups of 12 adults patients, scheduled for routine cardiac surgery. Each group was submitted to a different oxygenator design: group 1 to a high-pressure hollow-fiber membrane oxygenator (Sarns Turbo); group 2 to a medium-pressure hollow-fiber membrane oxygenator (Cobe optima); and group 3 to a flat-sheet membrane oxygenator (Cobe Duo). Although the investigated oxygenators have important differences in pressure drop and shear stress, no statistical differences were found in hemolysis generation or blood handling among the different groups. Actually, the study shows much higher shear stress levels over an average arterial cannula than over any of the evaluated oxygenators. The pressure drop over an oxygenator does not correlate well with shear stress and hemolysis because the dimensions of the system (radius and length) must be included in the calculation of shear stress from pressure drop.

References

Jun 1, 1987·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·M Lammers, A M Gressner
Sep 1, 1994·Annals of Biomedical Engineering·J D Hellums
Jan 1, 1994·Perfusion·F De SomerJ Delanghe

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Citations

Aug 5, 2005·Annals of Biomedical Engineering·Paul D GoodmanKenneth A Solen
Jan 30, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Kenneth Wong, Xuebin Li
Sep 29, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S KawahitoY Nosé
Nov 29, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Shinji KawahitoYukihiko Nosé
Dec 17, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Satyajeet Misra, Shrinivas Gadhinglajkar
Jun 24, 2017·Artificial Organs·Hai YuDominique Thévenin
Feb 24, 2018·Artificial Organs·Rik H J HendrixPatrick W Weerwind
Dec 12, 2018·Artificial Organs·Gemma RadleyCatherine A Thornton
Oct 3, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alexander WahbaUNKNOWN EACTS/EACTA/EBCP Committee Reviewers
Sep 7, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Wei YinDavid A Rubenstein
Nov 18, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Li Ying Koh, Nian Chih Hwang

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