Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load

NeuroImage. Clinical
Davneet S MinhasMilos D Ikonomovic

Abstract

The positron emission tomography (PET) radiotracer Pittsburgh Compound B ([C-11]PiB) demonstrates a high affinity for fibrillary amyloid-beta (Aβ) aggregates. However, [C-11]PiB's in vivo sensitivity and specificity is an ongoing area of investigation in correlation studies with postmortem measures of Aβ pathology. One potential confound in PET-to-postmortem correlation studies is the limited spatial resolution of PET and resulting partial volume effects (PVEs). In this work, we evaluated the impact of three partial volume correction (PVC) techniques - the Meltzer, the modified Müller-Gärtner, and the Region-Based Voxel-Wise - on correlations between region-matched in vivo [C-11]PiB standardized uptake value ratios (SUVRs) and postmortem measures of Aβ pathology in a unique cohort of nine subjects. Postmortem Aβ pathology was assessed histologically as percent area coverage of 6-CN-PiB positive and Aβ immunoreactive (4G8 antibody) deposits. The application of all three PVC techniques resulted in minimally reduced PET-to-postmortem correlations relative to no PVC. However, correlations to both 6-CN-PiB and 4G8 percent area across all PVC techniques and no PVC were statistically significant at p < 0.01, suggesting that PVC is of ...Continue Reading

Citations

Nov 27, 2018·Journal of Alzheimer's Disease : JAD·Christopher G SchwarzClifford R Jack
Aug 17, 2019·Frontiers in Neuroscience·Yuankai Zhu, Xiaohua Zhu
Nov 25, 2018·International Journal of Molecular Sciences·Grazia Daniela FemminellaNicola Ferrara
Feb 16, 2021·NeuroImage·Pawel J MarkiewiczFrederik Barkhof
Mar 17, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Christopher G Schwarz
May 4, 2021·Journal of Alzheimer's Disease : JAD·Wyllians Vendramini BorelliJaderson Costa da Costa

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