Impact of Pathogen Population Heterogeneity and Stress-Resistant Variants on Food Safety

Annual Review of Food Science and Technology
Tjakko AbeeH M W den Besten

Abstract

This review elucidates the state-of-the-art knowledge about pathogen population heterogeneity and describes the genotypic and phenotypic analyses of persister subpopulations and stress-resistant variants. The molecular mechanisms underlying the generation of persister phenotypes and genetic variants are identified. Zooming in on Listeria monocytogenes, a comparative whole-genome sequence analysis of wild types and variants that enabled the identification of mutations in variants obtained after a single exposure to lethal food-relevant stresses is described. Genotypic and phenotypic features are compared to those for persistent strains isolated from food processing environments. Inactivation kinetics, models used for fitting, and the concept of kinetic modeling-based schemes for detection of variants are presented. Furthermore, robustness and fitness parameters of L. monocytogenes wild type and variants are used to model their performance in food chains. Finally, the impact of stress-resistant variants and persistence in food processing environments on food safety is discussed.

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Citations

Dec 1, 2017·Frontiers in Microbiology·Bo-Hyung LeeThierry Bernardi
Jun 28, 2016·Applied and Environmental Microbiology·Karin I MetselaarHeidy M W den Besten
Oct 30, 2016·Applied and Environmental Microbiology·Elisa GayánAbram Aertsen
Mar 28, 2018·Annual Review of Food Science and Technology·Heidy M W den BestenMarcel H Zwietering
Sep 8, 2018·Frontiers in Microbiology·Nathan Horn, Arun K Bhunia
Sep 10, 2018·New Biotechnology·Amber L DoreyCatarina Marinho
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Amin N OlaimatRichard A Holley
Feb 2, 2021·Frontiers in Cellular and Infection Microbiology·Wolfgang EisenreichWerner Goebel
May 8, 2021·Comprehensive Reviews in Food Science and Food Safety·Erdogan CeylanHeidy M W den Besten
Jan 18, 2020·Microbiology Spectrum·Patrícia AntunesLuísa Peixe

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Methods Mentioned

BETA
aminoacylation

Software Mentioned

TAfinder

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