Impact of patient characteristics and infection type on clinical outcomes of patients who received linezolid or vancomycin for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: a pooled data analysis

Diagnostic Microbiology and Infectious Disease
Laura A PuzniakThomas P Lodise

Abstract

Phase III randomized, clinical trials are primarily designed to evaluate overall treatment-outcome comparisons. Although valuable data are gained from such comparisons, it is difficult to draw meaningful inferences about potential outcomes differences in specific patient groups and infection types. It is well established that clinical outcomes are dependent on host, treatment- and pathogen-related factors and understanding which groups benefit from one treatment relative to another is of great importance. This study sought to determine if clinical success in the treatment of complicated skin and skin structure infections (cSSSI) caused by methicillin resistant Staphylocccus aureus (MRSA) with linezolid or vancomycin varied across subpopulations and infection type. Data from 3 prospective, randomized trials evaluating linezolid and vancomycin for the treatment of MRSA cSSSI were pooled. Treatment related differences in outcomes were found, on both the absolute and relative scales, for most subpopulations and infection types. Identifying treatment differences in outcome by patient subpopulation can enhance clinical decision making.

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Citations

Jul 6, 2014·Current Infectious Disease Reports·Michael S PuliaLarissa May
Mar 17, 2015·Journal of the American Academy of Dermatology·Sarah J CoatesRichard D Granstein
Jun 19, 2009·Journal of the American Academy of Dermatology·Bruce StroberMelodie Young
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Dec 29, 2017·Current Opinion in Infectious Diseases·Alessia SavoldiEvelina Tacconelli

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