Impact of PCL nanofiber mat structural properties on hydrophilic drug release and antibacterial activity on periodontal pathogens

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Spela ZupancicKarin Kogermann

Abstract

Electrospinning enables to design and manufacture novel drug delivery systems capable of advancing the local antibacterial therapy. In this study, two hydrophilic drugs - metronidazole and ciprofloxacin hydrochloride - were loaded both individually and in combination into hydrophobic poly(ε-caprolactone) (PCL) matrix using electrospinning. We aimed to develop prolonged release drug delivery systems suitable for the treatment of periodontal diseases and understand how different rarely studied structural features, such as nanofiber mat thickness, surface area, wettability, together with intrinsic properties, like solid state and localization of incorporated drugs in nanofibers, affect the drug release. Furthermore, the safety of nanofiber mats was assessed in vitro on fibroblasts, and their antibacterial activity was tested on selected strains of periodontopathogenic bacteria. The results showed that the structural properties of nanofiber mat are crucial in particular drug-polymer combinations, affecting the drug release and consequently the antibacterial activity. The hydrophobicity of a PCL nanofiber mat and its thickness are the key characteristics in prolonged hydrophilic drug release, but only when wetting is the rate-limiti...Continue Reading

Citations

Dec 21, 2018·PloS One·Mirian Michelle Machado De PaulaAnderson Oliveira Lobo
Feb 19, 2019·Journal of Biomaterials Science. Polymer Edition·Emel TamahkarAdil Denizli
May 14, 2020·Expert Opinion on Drug Delivery·Maurício G C SousaOctávio L Franco
Dec 22, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Panna VassZsombor K Nagy
Jan 16, 2019·International Journal of Molecular Sciences·Minghan ChiHockin H K Xu
Nov 25, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xingzi LanYadong Tang
Mar 25, 2021·Expert Opinion on Drug Delivery·Anže ZidarŠpela Zupančič
Jul 2, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Špela Zupančič
May 28, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gisele Rodrigues Da SilvaFrancine Behar-Cohen
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Di SalleGianfranco Peluso

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