Impact of PD-L1 and T-cell inflamed gene expression profile on survival in advanced ovarian cancer.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
E HøgdallTorben Steiniche

Abstract

Programmed death ligand 1 (PD-L1) expression affects tumor evasion of immune surveillance. The prognostic value and relationship of PD-L1 expression to T-cell-inflamed immune signatures in ovarian cancer are unclear. The purpose of this study is to evaluate the impact of PD-L1 on overall survival and its correlation with an immune-mediated gene expression profile in patients with advanced ovarian cancer. PD-L1 expression in tumor and immune cells was assessed by immunohistochemistry, and PD-L1-positive expression was defined as a combined positive score ≥1; a T-cell-inflamed gene expression profile containing interferon γ response genes was evaluated using extracted RNA from surgical samples. Associations between PD-L1 expression, gene expression profile status, and overall survival were analyzed using the Kaplan-Meier method, log-rank test, and multivariate Cox proportional hazards regression models. A total of 376 patients with advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer treated by cytoreductive surgery and platinum-based therapy were included. PD-L1-positive expression was observed in 50.5% of patients and associated with more advanced stage (p=0.047), more aggressive histologic subtype (p=0.001...Continue Reading

References

Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Junzo HamanishiShingo Fujii
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Apr 14, 2016·Oncology Letters·Mei XuShi-Chao Zhuo
Jul 23, 2016·International Journal of Molecular Sciences·Gloria MitticaGiorgio Valabrega
Dec 3, 2016·Gynecologic Oncology Research and Practice·Stéphanie L GaillardBradley Monk
Dec 4, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Fred R HirschKeith M Kerr
Jun 27, 2017·The Journal of Clinical Investigation·Mark AyersTerrill K McClanahan
Oct 14, 2017·Journal of Gynecologic Oncology·Jun ZhuXiaohua Wu
Dec 18, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A OttJared K Lunceford
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Y RhaJ A Ajani
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ScottJ Walker

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Citations

Jul 20, 2021·Gynecologic Oncology·Maria RasmussenChristina Therkildsen

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