Impact of peginterferon alpha and ribavirin treatment on lipid profiles and insulin resistance in Hepatitis C virus/HIV-coinfected persons: the AIDS Clinical Trials Group A5178 Study.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Adeel A ButtACTG A5178 Study Team

Abstract

The effect of peginterferon alpha/ribavirin (PEG-IFN/RBV) and hepatitis C virus (HCV) clearance on lipid and insulin resistance (IR) profiles in HCV/human immunodeficiency virus (HIV) coinfection is unknown. We measured fasting total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoproteins (HDL-C), triglycerides (TG), glucose, and insulin at defined intervals in the A5178 study (N = 329), a prospective treatment trial in HCV/HIV coinfection. Changes from baseline and the relation between baseline values of these variables to sustained virologic response (SVR) were determined. Of 182 subjects with metabolic data, 98 achieved early virologic response (EVR) and continued PEG-IFN/RBV. Among those, median pretreatment HCV RNA was 6.6 log(10 )IU/mL; 73% had HCV genotype 1. Median pretreatment TC was 176 mg/dL (interquartile range [IQR],150-205]; median LDL-C was 99 mg/dL (IQR, 79-123); median HDL-C was 40 mg/dL (IQR, 31-47); and median TG was 147 mg/dL (IQR, 101-221). Median homeostasis model assessment of IR (HOMA-IR) was 3.3 (IQR, 1.7-5.3). The EVRs demonstrated a decline in TC, LDL-C, and HDL-C, whereas TG increased on treatment but returned to near baseline 24 weeks after end of treatment (EOT). The HOMA-IR de...Continue Reading

References

Jul 25, 2000·JAMA : the Journal of the American Medical Association·D L ThomasD Vlahov
Jun 28, 2003·Diabetes·Bruce B DuncanUNKNOWN Atherosclerosis Risk in Communities Study
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shruti H MehtaDavid L Thomas
Feb 28, 2004·Diabetes·Frank B HuJoAnn E Manson
May 28, 2005·Expert Review of Anti-infective Therapy·Adeel A Butt
Apr 17, 2007·HIV Clinical Trials·Scott R EvansUNKNOWN A5087 Study Team
Dec 5, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinichiro TadaToshifumi Hibi
Jun 11, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel A ButtAmy C Justice
Sep 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kathleen E CoreyRaymond T Chung
Feb 17, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Aymin Delgado-BorregoUNKNOWN Halt-C Trial Group
May 12, 2010·World Journal of Gastroenterology : WJG·Chao-Hung HungChuan-Mo Lee
Jun 23, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen A HarrisonMark S Sulkowski
Aug 7, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Darmendra RamcharranUNKNOWN Virahep-C Study Group
Aug 24, 2010·European Journal of Gastroenterology & Hepatology·Christian M LangeStefan Zeuzem
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsuya FujinoMunechika Enjoji
Oct 6, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kenneth E ShermanUNKNOWN AIDS Clinical Trials Group A5178 Study Team
Nov 13, 2010·Gastroenterology·Hari S ConjeevaramUNKNOWN Virahep-C Study Group
Jun 1, 2011·Alimentary Pharmacology & Therapeutics·M EslamM Romero-Gomez
Jul 12, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yuan-Hung KuoChuan-Mo Lee
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Eric ChakSammy Saab

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Citations

Nov 26, 2015·Gastroenterology Clinics of North America·Shilpa Lingala, Marc G Ghany
Sep 26, 2015·Lipids in Health and Disease·Sadia Qamar ArainNaseem Aslam Channa
Nov 21, 2019·Alimentary Pharmacology & Therapeutics·Chia-Chi WangJia-Horng Kao
Feb 19, 2013·Expert Review of Vaccines·Bertrand Bellier, David Klatzmann

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