Impact of peripheral artery disease on prognosis in hospitalized heart failure patients

Circulation Journal : Official Journal of the Japanese Circulation Society
Yuichi NakamuraYasuchika Takeishi

Abstract

The impact of peripheral artery disease (PAD) on heart failure (HF) prognosis remains unclear. A total of 388 consecutive decompensated HF patients were divided into 2 groups based on the presence of PAD: HF with PAD (PAD group, n=101, 26.0%) and HF without PAD (non-PAD group, n=287, 74.0%). We compared clinical features, echocardiographic parameters, cardiopulmonary exercise testing results, laboratory findings, as well as cardiac, non-cardiac, and all-cause mortality between the 2 groups. The PAD group, as compared with the non-PAD group, had (1) higher prevalence of coronary artery disease (40.6 vs. 27.5%, P=0.011) and cerebrovascular disease (34.7 vs. 18.2%, P=0.001); (2) higher tumor necrosis factor-α (1.82 vs. 1.49 pg/ml, P=0.023), C-reactive protein (0.32 vs. 0.19 mg/dl, P=0.045), and troponin T (0.039 vs. 0.021 ng/ml, P=0.019); (3) lower LVEF (42.4 vs. 48.5%, P<0.001); (4) lower peak V̇O2(13.4 vs. 15.9 ml·kg(-1)·min(-1), P=0.001); and (5) higher V̇E/V̇CO2slope (38.8 vs. 33.7, P<0.001). On Kaplan-Meier analysis, cardiac, non-cardiac, and all-cause mortality were significantly higher in the PAD group than in the non-PAD group (P<0.05, respectively). On Cox proportional hazard analysis after adjusting for confounding facto...Continue Reading

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Jan 24, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichi NakamuraYasuchika Takeishi
Feb 5, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Miguel Ruiz-Canela, Miguel A Martínez-González
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Citations

Mar 11, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsuya Matoba
May 20, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuki KannoYasuchika Takeishi
Aug 9, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichiro TomaYusuke Ohya
Jun 20, 2019·Asian Cardiovascular & Thoracic Annals·Hiroshi KurazumiShigeru Ikenaga
Jun 28, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Akiomi YoshihisaYasuchika Takeishi
Sep 19, 2019·Journal of Physical Therapy Science·Shinsuke ImaokaToshio Higashi
Oct 27, 2020·Journal of the American Heart Association·Zainali ChunawalaMelissa C Caughey
Apr 20, 2021·Frontiers in Cardiovascular Medicine·Koichiro WatanabeYasuchika Takeishi
Sep 29, 2020·Journal of Atherosclerosis and Thrombosis·Yu SatoYasuchika Takeishi

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