Impact of Phosphorus-Based Food Additives on Bone and Mineral Metabolism

The Journal of Clinical Endocrinology and Metabolism
Orlando M GutiérrezGeorge R Beck

Abstract

Phosphorus-based food additives can substantially increase total phosphorus intake per day, but the effect of these additives on endocrine factors regulating bone and mineral metabolism is unclear. This study aimed to examine the effect of phosphorus additives on markers of bone and mineral metabolism. Design and Setting, and Participants: This was a feeding study of 10 healthy individuals fed a diet providing ∼1000 mg of phosphorus/d using foods known to be free of phosphorus additives for 1 week (low-additive diet), immediately followed by a diet containing identical food items; however, the foods contained phosphorus additives (additive-enhanced diet). Parallel studies were conducted in animals fed low- (0.2%) and high- (1.8%) phosphorus diets for 5 or 15 weeks. The changes in markers of mineral metabolism after each diet period were measured. Participants were 32 ± 8 years old, 30% male, and 70% black. The measured phosphorus content of the additive-enhanced diet was 606 ± 125 mg higher than the low-additive diet (P < .001). After 1 week of the low-additive diet, consuming the additive-enhanced diet for 1 week significantly increased circulating fibroblast growth factor 23 (FGF23), osteopontin, and osteocalcin concentration...Continue Reading

Associated Clinical Trials

Jul 14, 2011·Orlando M. Gutierrez, MD, MMSc
Feb 15, 2019·Orlando M. Gutierrez, MD, MMSc

Citations

Nov 21, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alex R ChangLawrence J Appel
Oct 14, 2017·The Journal of Clinical Endocrinology and Metabolism·Junichi IshigamiKunihiro Matsushita
Jul 10, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Philippe ChauveauMichel Aparicio
Feb 26, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Julia J Scialla, Pao-Hwa Lin
Aug 23, 2019·Journal of Human Hypertension·Scott T McClureLawrence J Appel
Jul 19, 2017·Annual Review of Nutrition·Lindsay R Pool, Myles Wolf
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Aug 26, 2017·Current Osteoporosis Reports·Colby J VorlandKathleen M Hill Gallant
Jun 11, 2020·Nutrients·Alicja Ewa RatajczakIwona Krela-Kaźmierczak
Mar 5, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Carlos CuervoMichael Freundlich
Jan 7, 2020·International Journal of Endocrinology and Metabolism·Cecilie Siggaard JørgensenNiels Holtum Birkebæk
Jan 20, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yasuyuki FujiiI-Ping Chen
Jun 27, 2020·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Fiona N ByrneJoseph Eustace
Nov 11, 2018·Seminars in Nephrology·Joseph Lunyera, Julia J Scialla
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eliza MatuszewskaJan Matysiak
Jul 13, 2021·Critical Reviews in Food Science and Nutrition·Danjun GuoTao Hou
Nov 4, 2021·Current Osteoporosis Reports·Orlando M Gutiérrez

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