Impact of Physical Exercise on Growth and Progression of Cancer in Rodents-A Systematic Review and Meta-Analysis

Frontiers in Oncology
Robert-Christopher Karl-Richard EschkePhilipp Zimmer

Abstract

Background: Physical exercise is suspected to reduce cancer risk and mortality. So far, little is known about the underlying mechanisms. Although limited, murine models represent a promising attempt in order to gain knowledge in this field. Objective: A systematic review and meta-analysis examining various treatment protocols was conducted in order to determine the impact of exercise on tumor growth in rodents. Methods: PubMed, Google scholar and System for information on Gray literature in Europe were screened from inception to October 2017. Risk of bias within individual studies was assessed using the Office of Health Assessment and Translation risk of bias rating tool for human and animal trials. The effect of exercise on tumor growth over and above non-exercise control was pooled using random-effects model. Subgroup analyses were conducted to identify potential moderators. Results: The quality of the included 17 articles ranged between "probably low" and "high risk of bias." A significant reduction in tumor growth in exercising animals compared to controls was detected (Hedges' g = -0.40; 95% CI -0.66 to -0.14, p < 0.01) with between-study heterogeneity (τ2 = 0.217, I2 = 70.28%, p < 0.001). The heterogeneity was partially e...Continue Reading

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Citations

Mar 17, 2020·Antioxidants & Redox Signaling·Ruy Andrade Neto LouzadaRodrigo Soares Fortunato
Jul 25, 2020·International Journal of Sports Medicine·Anasua PalKaren Steindorf
Apr 4, 2021·Sports·Polyxeni SpiliopoulouGerasimos Terzis
Apr 14, 2021·Journal of Physical Activity & Health·Mário EstevesJosé A Duarte
Apr 18, 2021·European Journal of Applied Physiology·Richard S MetcalfeSamuel T Orange
Aug 4, 2021·International Journal of Sports Medicine·Mário EstevesJose Alberto Duarte
Aug 27, 2021·Metabolites·Alessandra RenziniLuca Madaro
Aug 31, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Michael A Chapek, Robert G Martindale

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Software Mentioned

OHAT
Comprehensive Meta - Analysis
SIGLE ( System

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