Impact of piroxicam beta-cyclodextrin on the efficacy of the intrauterine device in a rat model

The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception
S OzalpH Hassa


To elucidate the effect of piroxicam beta-cyclodextrin (PbetaCD), a non-steroidal anti-inflammatory drug (NSAID), on the efficacy of the intrauterine device (IUD) in a rat model. Forty nulliparous female Wistar rats were allocated to one of four groups, comprising each 10 of these animals. Group I: neither IUD nor medication; group II: IUD, but no medication; group III: IUD and PbetaCD; and group IV: PbetaCD only. In groups II and III, a string of 3/0 silk suture of 2 cm long was transcervically placed in one of the horns of the bicornuate uterus of the rat. Rats in group III were treated during the 18 days following IUD placement with 3 mg/kg/day PbetaCD administered via a feeding tube; group IV received PbetaCD for the same length of time, but had no IUD inserted. The rats were then mated. Thereafter, vaginal smears were taken and assessed daily, in the early morning, for the presence of spermatozoa. The day when spermatozoa were detected was considered to be the first day of gestation. On gestational day 19, both uterine horns of all rats were evaluated for the presence and number of embryos. In group II, mean embryo counts in the horn with or without IUD were 1.0 +/- 0.2 and 4.5 +/- 0.3, respectively (p < 0.01). The compari...Continue Reading


Nov 1, 1978·Journal of Reproduction and Fertility·C A Evans, T G Kennedy
Jan 1, 1985·Archives of Toxicology·C N Aguwa
Jun 1, 1971·Fertility and Sterility·S el-Sahwi, D L Moyer
Oct 3, 1999·Molecular Human Reproduction·L Marions, K G Danielsson
Oct 24, 2001·Contraception·A S SalhabB I Amro
Jun 12, 2002·Contraception·Nongluck Sookvanichsilp, Pawitra Pulbutr
Oct 21, 2005·Reproductive Biology and Endocrinology : RB&E·Elsebeth Staun-Ram, Eliezer Shalev

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Mar 17, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Irving Sivin, István Batár

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