Abstract
Aldosterone promotes vascular smooth muscle cell proliferation and endothelial dysfunction, suggesting the contribution to in-stent restenosis (ISR). This study evaluated any relation between plasma aldosterone levels and ISR 6 months after successful coronary stenting. We enrolled 156 consecutive patients with stable angina who underwent coronary bare metal stenting. Plasma aldosterone levels and other serum markers known to influence cardiovascular events were measured in all patients at baseline. Patients with restenosis were found to have significantly higher plasma aldosterone levels than their counterparts without restenosis (162 +/- 60 vs 122 +/- 60 pg/ml, p = 0.007). On logistic regression analysis, even after adjusting for clinical, angiographic, and other confounding variables, plasma aldosterone level per 10 pg/ml (odds ratio 1.34, 95% confidence interval 1.10 to 1.63, p = 0.006) proved to be the independent predictor of ISR. The area under the receiver-operating characteristic curve for plasma aldosterone level was 0.75, and the optimal cut-off value identified by receiver-operating characteristic analysis was 141.9 pg/ml, which had a predictive accuracy of 69%. In conclusion, the present findings indicate that plas...Continue Reading
References
Jul 18, 1995·European Journal of Pharmacology·U IkedaK Shimada
Aug 16, 2001·Trends in Endocrinology and Metabolism : TEM·R Rocha, C T Stier
Jul 10, 2002·Hypertension·Mitsuhide NaruseKazue Takano
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ricardo RochaJohn A Delyani
Apr 17, 2003·Endocrinology·Tae-Yon ChunJ Howard Pratt
Jun 7, 2003·Circulation Research·Wenning QinEllen G McMahon
Aug 29, 2003·American Journal of Hypertension·Atsuhisa Sato, Takao Saruta
Citations
Jun 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yongji YanXu Zhang
Sep 4, 2008·Current Hypertension Reports·Kohzo Nagata
Apr 24, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Stefan Peters
Sep 1, 2014·American Heart Journal·Pil Sang SongUNKNOWN Other Korea Acute Myocardial Infarction Registry Investigators
Jul 14, 2014·Seminars in Nephrology·Juan TamargoLuis M Ruilope
Feb 5, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Hongjun JinZhude Tu
May 23, 2012·Heart, Lung & Circulation·Shu-Qin LiuLe-Xin Wang
Jul 11, 2012·Clinical Cardiology·Mindy MarkowitzNeil L Coplan
Apr 8, 2014·European Journal of Heart Failure·Javaid IqbalFaiez Zannad
Aug 1, 2006·The American Journal of Pathology·Yasuhiro NakamuraHironobu Sasano
Jan 22, 2013·Current Opinion in Pharmacology·Carolin Zwadlo, Johann Bauersachs
Jun 9, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Stefan PetersChristian Richter
Aug 22, 2018·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yukari TakasagoAoi Ono
Dec 6, 2006·Circulation·Euan A AshleyThomas Quertermous
Jan 20, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Iris Z JaffeMichael E Mendelsohn
Sep 20, 2017·PloS One·Jochen DutzmannDaniel G Sedding
Jan 6, 2018·Physiological Research·K KarolczakC Watala
Apr 22, 2008·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Stefan Peters