Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: A prospective observational study

Clinical Hemorheology and Microcirculation
David N NaumannSam D Hutchings

Abstract

Preclinical studies report that higher plasma viscosity improves microcirculatory flow after haemorrhagic shock and resuscitation, but no clinical study has tested this hypothesis. We investigated the relationship between plasma viscosity and sublingual microcirculatory flow in patients during resuscitation for traumatic haemorrhagic shock (THS). Sublingual video-microscopy was performed for 20 trauma patients with THS as soon as feasible in hospital, and then at 24 h and 48 h. Values were obtained for total vessel density, perfused vessel density, proportion of perfused vessels, microcirculatory flow index (MFI), microcirculatory heterogeneity index (MHI), and Point of Care Microcirculation (POEM) scores. Plasma viscosity was measured using a Wells-Brookfield cone and plate micro-viscometer. Logistic regression analyses examined relationships between microcirculatory parameters and plasma viscosity, adjusting for covariates (systolic blood pressure, heart rate, haematocrit, rate and volume of fluids, and rate of noradrenaline). Higher plasma viscosity was not associated with improved microcirculatory parameters. Instead, there were weakly significant associations between higher plasma viscosity and lower (poorer) MFI (p = 0.04...Continue Reading

References

Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·E Christiaan BoermaCan Ince
Sep 12, 2007·Critical Care : the Official Journal of the Critical Care Forum·Daniel De BackerCan Ince
Jan 6, 2009·Transfusion Alternatives in Transfusion Medicine : TATM·C LenzT Frietsch
May 13, 2009·Clinical Hemorheology and Microcirculation·Oguz K BaskurtUNKNOWN International Expert Panel for Standardization of Hemorheological Methods
Apr 19, 2011·Current Opinion in Critical Care·Anatole HarroisJacques Duranteau
Aug 31, 2011·Clinical Hemorheology and Microcirculation·F JungR Sternitzky
Nov 22, 2011·The American Journal of Emergency Medicine·Catalina MessmerPedro Cabrales
Feb 25, 2014·Critical Care Medicine·Guillaume TachonJacques Duranteau
Dec 26, 2015·Current Opinion in Anaesthesiology·Ross A Davenport, Karim Brohi
Jan 6, 2016·Critical Care : the Official Journal of the Critical Care Forum·Can Ince
Oct 8, 2016·Critical Care : the Official Journal of the Critical Care Forum·David N NaumannSam D Hutchings
Dec 10, 2016·Best Practice & Research. Clinical Anaesthesiology·Jan Bakker
May 26, 2017·Current Opinion in Critical Care·Michael E Kiyatkin, Jan Bakker
Oct 19, 2017·Clinical Hemorheology and Microcirculation·Nivin SharawyChristian Lehmann
Nov 4, 2017·Anesthesia and Analgesia·Huaiwu HeCan Ince

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection

Clinical Trials Mentioned

NCT02111109

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.