Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes.

Biomedicines
Midori FujishiroAkifumi Kushiyama

Abstract

To unravel associations between plasma xanthine oxidoreductase (XOR) and diabetic vascular complications, especially distal symmetric polyneuropathy (DSP), we investigated plasma XOR activities using a novel assay. Patients with type 2 diabetes mellitus (T2DM) with available nerve conduction study (NCS) data were analyzed. None were currently taking XOR inhibitors. XOR activity of fasting blood samples was assayed using a stable isotope-labeled substrate and LC-TQMS. JMP Clinical version 5.0. was used for analysis. We analyzed 54 patients. Mean age was 64.7 years, mean body mass index was 26.0 kg/m2, and mean glycated hemoglobin was 9.4%. The logarithmically transformed plasma XOR activity (ln-XOR) correlated positively with hypoxanthine, xanthine, visceral fatty area, and liver dysfunction but negatively with HDL cholesterol. ln-XOR correlated negatively with diabetes duration and maximum intima-media thickness. Stepwise multiple regression analysis revealed ln-XOR to be among selected explanatory factors for various NCS parameters. Receiver operating characteristic curves showed the discriminatory power of ln-XOR. Principal component analysis revealed a negative relationship of ln-XOR with F-waves as well as positive relation...Continue Reading

References

Apr 6, 1999·Radiology·T YoshizumiY Matsuzawa
Jan 28, 2005·The New England Journal of Medicine·Solomon TesfayeUNKNOWN EURODIAB Prospective Complications Study Group
Sep 24, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·U R KuppusamyP Rokiah
May 22, 2007·Metabolism: Clinical and Experimental·Jen-Der LinHsiao-Fen Weng
Aug 23, 2007·JAMA : the Journal of the American Medical Association·Quresh MohamedTien Y Wong
Jul 12, 2008·Journal of Occupational and Environmental Medicine·Theodore N ArmstrongBradley A Evanoff
Sep 30, 2010·Diabetes Care·Solomon TesfayeUNKNOWN Toronto Diabetic Neuropathy Expert Group
Feb 1, 2011·Annals of the New York Academy of Sciences·Yingfeng Deng, Philipp E Scherer
Mar 4, 2011·The New England Journal of Medicine·Sreenivasa Rao Kondapally SeshasaiUNKNOWN Emerging Risk Factors Collaboration
May 23, 2012·Lancet Neurology·Brian C CallaghanEva L Feldman
Aug 21, 2013·PloS One·Josephe Archie HonoratYuji Nakatsuji
Apr 2, 2014·International Journal of Endocrinology·Jianfei XiaFeifei Zhang
Jun 3, 2014·Biochimica Et Biophysica Acta·Maria Giulia BattelliLetizia Polito
Dec 21, 2014·Clinical and Experimental Nephrology·Masakazu HanedaKenichiro Shide
Nov 7, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Takayo MuraseTakashi Nakamura
Dec 15, 2016·Journal of Diabetes Research·Dijana J MiricDragana Puhalo-Sladoje
Dec 22, 2016·Diabetes Care·Rodica Pop-BusuiDan Ziegler
Apr 14, 2017·Metabolism: Clinical and Experimental·Kahori Watanabe WashioHidenori Koyama
Jun 3, 2017·Journal of Diabetes Research·Akihiko AndoShun Ishibashi
Mar 7, 2018·Metabolism: Clinical and Experimental·Leonardo SpatolaMarco Dauriz
Apr 3, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·O Binns-HallS Tesfaye
Jun 23, 2018·Biochemical and Biophysical Research Communications·Dan-Dan ZhuZhi Zheng
Jun 25, 2018·Heart and Vessels·Ken WatanabeMasafumi Watanabe
Dec 7, 2019·Nature Medicine·David FurmanGeorge M Slavich
Jan 10, 2020·Journal of Diabetes Investigation·Masato FuruhashiTetsuji Miura
Nov 20, 2020·Journal of Diabetes Investigation·Yusuke KawachiIichiro Shimomura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.