Impact of Pneumococcal Conjugate Universal Routine Vaccination on Pneumococcal Disease in Italian Children

Journal of Immunology Research
Francesca FortunatoRosa Prato

Abstract

In Italy, the effectiveness of pneumococcal universal vaccination in preventing vaccine-type invasive pneumococcal disease (IPD) in the PCV7/PCV13 shifting period was estimated to be 84.3% (95% CI: 84.0-84.6%) in children <5 years. This study aims at corroborating the estimation of both the effectiveness (VE) of PCVs and its impact in reducing pneumococcal diseases. A 1:3 matched-case-control study was conducted among children <5 years old hospitalized for IPD or pneumococcal pneumonia (PP) between 2006 and 2012 in the Puglia region. Moreover, hospitalizations for pneumococcal outcomes in the pre- and postvaccination period and the hospitalization risk ratios (HRRs) with 95% CIs were computed in Italy and in the first eight regions that introduced PCVs in 2006. The overall effectiveness of PCVs was 75% (95% CI: 61%-84%); it was 69% (95% CI: 30%-88%) against IPD and 77% (95% CI: 61%-87%) against PP. PCVs showed a significant impact on IPD and acute otitis media either at a national level or in those regions with a longer vaccination history, with a nearly 40% reduction of hospitalizations for both outcomes. Our findings provide further evidence of the effectiveness of PCVs against pneumococcal diseases and its impact on nasophar...Continue Reading

References

Feb 15, 2001·The New England Journal of Medicine·J EskolaUNKNOWN Finnish Otitis Media Study Group
Oct 28, 2011·Health Policy·Valeria AlfonsiUNKNOWN Regional Coordinators for Infectious Diseases and Vaccinations
Feb 14, 2012·The Pediatric Infectious Disease Journal·Sean P FitzwaterHope L Johnson
Feb 15, 2012·The Pediatric Infectious Disease Journal·Robert CohenEmmanuelle Varon
May 25, 2012·Vaccine·UNKNOWN WHO Publication
Sep 8, 2012·BMC Infectious Diseases·Catherine Weil-OlivierLorenzo Mantovani
Dec 18, 2013·The Pediatric Infectious Disease Journal·Cynthia G WhitneyKatherine L O'Brien
Jul 19, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zitta Barrella HarboePalle Valentiner-Branth
Aug 26, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A TorresT Welte

❮ Previous
Next ❯

Citations

Nov 24, 2016·The Pediatric Infectious Disease Journal·Tal MaromSharon Ovnat Tamir
Jul 16, 2019·Expert Review of Vaccines·Viviane Maimoni GonçalvesEliane Namie Miyaji
Dec 27, 2019·The Pediatric Infectious Disease Journal·Paola MarchisioElena Chiappini

❮ Previous
Next ❯

Software Mentioned

Stata MP

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.