Impact of Pneumococcal Conjugate Vaccine Administration in Pediatric Older Age Groups in Low and Middle Income Countries: A Systematic Review

PloS One
Kimberly BonnerJennifer Cohn

Abstract

Pneumococcal conjugate vaccine (PCV) is included in the World Health Organization's routine immunization schedule and is recommended by WHO for vaccination in high-risk children up to 60 months. However, many countries do not recommend vaccination in older age groups, nor have donors committed to supporting extended age group vaccination. To better inform decision-making, this systematic review examines the direct impact of extended age group vaccination in children over 12 months in low and middle income countries. An a priori protocol was used. Using pre-specified terms, a search was conducted using PubMed, LILACS, Cochrane Infectious Diseases Group Specialized Register, Cochrane Central Register of Controlled Trials, CAB Abstracts, clinicaltrials.gov and the International Symposium on Pneumococci and Pneumococcal Diseases abstracts. The primary outcome was disease incidence, with antibody titers and nasopharyngeal carriage included as secondary outcomes. Eighteen studies reported on disease incidence, immune response, and nasopharyngeal carriage. PCV administered after 12 months of age led to significant declines in invasive pneumococcal disease. Immune response to vaccine type serotypes was significantly higher for those va...Continue Reading

References

Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
May 6, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Aug 30, 2008·Annals of Tropical Paediatrics·R IrisoA Kisayke
Mar 17, 2011·The Pediatric Infectious Disease Journal·María Catalina PírezAlicia Montano
Apr 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M Musher
May 25, 2012·Vaccine·UNKNOWN WHO Publication
Jun 16, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A RocaR A Adegbola
Sep 5, 2012·Tropical Medicine & International Health : TM & IH·Xavier Bosch-CapblanchA Burton
Apr 16, 2013·Lancet·Christa L Fischer WalkerRobert E Black
Apr 15, 2014·The Lancet. Respiratory Medicine·Carla Magda Allan S DominguesUNKNOWN Brazilian Pneumococcal Conjugate Vaccine Effectiveness Study Group
Aug 12, 2014·The Lancet Global Health·Keith P Klugman

❮ Previous
Next ❯

Citations

Mar 1, 2017·Tropical Medicine & International Health : TM & IH·James M Stuart
Jul 14, 2017·Pneumonia·Serena TricaricoStuart C Clarke

❮ Previous
Next ❯

Software Mentioned

PRIMSA

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.