Impact of Policies on the Rise in Sepsis Incidence, 2000-2010

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Shruti K GohilCenters for Disease Control and Prevention Epicenters Program

Abstract

Sepsis hospitalizations have increased dramatically in the last decade. It is unclear whether this represents an actual rise in sepsis illness or improved capture by coding. We evaluated the impact of Centers of Medicare and Medicaid Services (CMS) guidance after newly introduced sepsis codes and medical severity diagnosis-related group (MS-DRG) systems on sepsis trends. In this retrospective cohort study of California hospitalizations from January 2000 to December 2010, sepsis was identified by International Classification of Diseases, Ninth Revision (ICD-9) coding (Dombrovskiy method). Sepsis-associated mortality rates were calculated. Logistic regression models evaluated variables associated with sepsis and mortality. Segmented regression time series analysis assessed changes in sepsis frequency for (1) baseline (January 2000 to September 2003); (2) post-CMS guidelines on sepsis coding (October 2003 to September 2007); and (3) after the introduction of MS-DRG (October 2007 to December 2010). Annual hospitalizations with sepsis diagnoses tripled within a decade, from 21.1 to 59.9 cases per 1000 admissions, with a 2.8- and 2.0-fold increase in severe and nonsevere sepsis, respectively, whereas annual admissions remained unchan...Continue Reading

References

Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Aug 14, 2002·Journal of Clinical Pharmacy and Therapeutics·A K WagnerD Ross-Degnan
Apr 28, 2004·Journal of General Internal Medicine·Sebastian SchneeweissRobert J Glynn
Aug 3, 2004·Critical Care Medicine·H Bryant NguyenMichael C Tomlanovich
Dec 24, 2005·Critical Care Medicine·Greg S MartinMarc Moss
May 15, 2007·Medical Care·Lisa I Iezzoni
May 23, 2009·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Alan H RosensteinKen Taylor
Aug 20, 2011·Chest·Gagan KumarUNKNOWN Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators
Oct 4, 2011·Critical Care Medicine·Tara LaguPeter K Lindenauer
Apr 5, 2012·JAMA : the Journal of the American Medical Association·Peter K LindenauerMichael B Rothberg
Apr 21, 2012·Journal of Critical Care·Tara LaguPeter K Lindenauer
Jun 28, 2012·Expert Review of Anti-infective Therapy·Greg S Martin
Jan 29, 2013·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
Feb 28, 2013·Critical Care Medicine·David F GaieskiBrendan G Carr
Mar 19, 2014·JAMA : the Journal of the American Medical Association·Theodore J Iwashyna, Derek C Angus
Mar 19, 2014·JAMA : the Journal of the American Medical Association·Kirsi-Maija KaukonenRinaldo Bellomo
Apr 18, 2014·The New England Journal of Medicine·Chanu RheeMichael Klompas
Sep 27, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chanu RheeUNKNOWN Centers for Disease Control and Prevention Epicenters Program

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Citations

Jan 21, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valerie C Cluzet, Ebbing Lautenbach
Oct 30, 2016·Annals of Epidemiology·S Reza JafarzadehDavid K Warren
Feb 6, 2017·American Journal of Respiratory and Critical Care Medicine·Tài Pham, Gordon D Rubenfeld
Aug 18, 2017·Critical Care Medicine·Henry E WangJohn P Donnelly
Feb 17, 2018·Intensive Care Medicine·Jean-Louis VincentUNKNOWN SOAP investigators
Feb 14, 2018·Critical Care Medicine·Ninad S ChaudharyHenry E Wang
Jun 5, 2018·Health Affairs·Laura BurkeAshish K Jha
Feb 10, 2018·Journal of Paediatrics and Child Health·Chia-Hung YoUNKNOWN National Taiwan University Hospital Health Economics and Outcome Research Group
Mar 31, 2018·The Pediatric Infectious Disease Journal·James T GaensbauerJames K Todd
Feb 16, 2019·Critical Care Medicine·Steven Q Simpson
Apr 20, 2019·Emerging Infectious Diseases·Louise Thorlacius-UssingThomas Benfield
Oct 12, 2019·Health Services Research·Jason D BuxbaumAndrew M Ryan
Feb 11, 2020·Journal of General Internal Medicine·Jonathan D BaghdadiRobert Brook
Feb 15, 2020·Critical Care Medicine·Chanu Rhee, Michael Klompas
Feb 27, 2019·Journal of Clinical Gastroenterology·Jessica B RubinJennifer C Lai
Apr 15, 2017·Intensive Care Medicine·T TängdénUNKNOWN Infection Section for the European Society of Intensive Care Medicine, the Pharmacokinetics and Pharmacodynamics Study Group
Jul 22, 2020·The Journal of Infectious Diseases·Claire N ShappellChanu Rhee
Sep 28, 2017·Open Forum Infectious Diseases·Paul J HugganRoss Lawrenson
Feb 29, 2020·BMJ Quality & Safety·Claire N Shappell, Chanu Rhee
Dec 16, 2018·Intensive Care Medicine·Meri R J Varkila, Olaf L Cremer
Aug 28, 2020·Health Services Research·Michelle S KellerNadereh Pourat
May 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chanu RheeMichael Klompas
Oct 21, 2020·Annals of Intensive Care·Claire DupuisJean-François Timsit
Jan 26, 2021·Current Opinion in Anaesthesiology·Catherine Chiu, Matthieu Legrand
May 29, 2021·Journal of Gerontological Nursing·Aldrin U NievesAlisa J Estey

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