Impact of polyunsaturated fatty acids on cytoskeletal linkage of L-selectin

Cellular Immunology
Jeff G Leid, M A Jutila

Abstract

Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expression of L-selectin as well as a highly conserved epitope on L-selectin that may serve as a marker for optimal protein function. Additionally, PUFA enrichment inhibited L-selectin cytoskeletal association, which is thought to be important for optimal functional activity. In support of this, PUFA enrichment of gammadelta T cell membranes reduced L-selectin-dependent rolling interactions under conditions mimicking physiological flow. Taken together, these data suggest that the anti-inflammatory activity of omega-3 polyunsaturated fatty acids may be due, in part, to a novel effect on L-selectin, namely PUFA reduction or prevention of cytoskeletal association of L-selectin.

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Citations

Apr 11, 2013·Human Vaccines & Immunotherapeutics·Carina RosenbergEskild Petersen
Mar 25, 2005·American Journal of Physiology. Cell Physiology·Polly E MattilaBruce Walcheck
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeff G LeidAlyssa K Jeffers
May 15, 2015·Lipids in Health and Disease·Simone SchmidtAndreas Hahn

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