Impact of population age structure on Wolbachia transgene driver efficacy: ecologically complex factors and release of genetically modified mosquitoes

Insect Biochemistry and Molecular Biology
Jason L Rasgon, Thomas W Scott

Abstract

Wolbachia symbionts hold theoretical promise as a way to drive transgenes into insect vector populations for disease prevention. For simplicity, current models of Wolbachia dynamics and spread ignore ecologically complex factors such as the age structure of vector populations and overlapping vector generations. We developed a model including these factors to assess their impact on the process of Wolbachia spread into populations of three mosquito species (Anopheles gambiae, Aedes aegypti and Culex pipiens). Depending on the mosquito species, Wolbachia parameters, released mosquito life stage and initial age structure of the target population, the number of Wolbachia-infected mosquitoes that we predict would need to be released ranged from less than the threshold calculated by the simple model to a 10-30-fold increase. Transgenic releases into age-structured populations, which is an expectation for wild mosquitoes, will be difficult and depending on the circumstances may not be economically or logistically feasible due to the large number of infected mosquitoes that must be released. Our results support the perspective that understanding ecological factors is critical for designing transgenic vector-borne disease control strateg...Continue Reading

References

Jan 31, 1977·Journal of Medical Entomology·C GómezC E Machado-Allison
Jun 1, 1968·Annals of Tropical Medicine and Parasitology·W W MacdonaldM Maung Tun
Apr 13, 2000·Annual Review of Entomology·J Hemingway, H Ranson
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B J Beaty
May 25, 2001·Journal of Medical Entomology·N MinakawaG Yan
May 25, 2001·Journal of Medical Entomology·L C HarringtonT W Scott
Mar 12, 2002·Proceedings. Biological Sciences·Stephen L DobsonFrancis M Jiggins
May 25, 2002·Nature·Junitsu ItoMarcelo Jacobs-Lorena
Jun 8, 2002·Journal of Theoretical Biology·Peter Schofield
Oct 5, 2002·Science·Thomas W ScottChristophe Boëte
Apr 16, 2003·Journal of Medical Entomology·Jason L RasgonThomas W Scott

❮ Previous
Next ❯

Citations

Mar 17, 2010·Bulletin of Mathematical Biology·József Z Farkas, Peter Hinow
May 14, 2009·Heredity·J Engelstädter, A Telschow
Jun 8, 2012·Journal of the Royal Society, Interface·Penelope A Hancock, H Charles J Godfray
Sep 5, 2006·Applied and Environmental Microbiology·Jason L RasgonXiaoxia Ren
Oct 7, 2011·BMC Evolutionary Biology·Philip R CrainStephen L Dobson
May 8, 2008·BMC Evolutionary Biology·Max ReuterFrédéric Guillaume
Aug 24, 2013·PLoS Neglected Tropical Diseases·Jan MedlockAlison P Galvani
Jun 24, 2009·Ecological Applications : a Publication of the Ecological Society of America·Nicholas J Bax, Ronald E Thresher
Feb 1, 2014·Evolution, Medicine, and Public Health·James J Bull, Michael Turelli
Sep 15, 2007·Journal of the American Mosquito Control Association·Cynthia C Lord
Apr 5, 2011·The American Naturalist·Penelope A HancockH Charles J Godfray
Jul 2, 2016·Scientific Reports·Matthew T AliotaJorge E Osorio
Feb 2, 2018·Pathogens and Global Health·Rebeca Carballar-Lejarazú, Anthony A James
Jan 22, 2009·Evolution; International Journal of Organic Evolution·Ralph Haygood, Michael Turelli
May 1, 2009·Evolutionary Applications·Yunxin HuangFred Gould
Aug 19, 2009·Evolution; International Journal of Organic Evolution·Michael Turelli
Feb 16, 2013·Nature Reviews. Microbiology·Elizabeth A McGraw, Scott L O'Neill
May 1, 2011·Evolutionary Applications·Yunxin HuangFred Gould
Apr 29, 2016·PLoS Neglected Tropical Diseases·Matthew T AliotaJorge E Osorio
Jan 18, 2017·Journal of Mathematical Biology·József Z FarkasAbdul-Aziz Yakubu
Jun 9, 2009·Evolution; International Journal of Organic Evolution·Lauren B CarringtonAry A Hoffmann
Nov 17, 2017·The American Journal of Tropical Medicine and Hygiene·Muhammad Sajjad SarwarFatima Shahbaz
Nov 1, 2020·Biological Reviews of the Cambridge Philosophical Society·Ehsan SanaeiJan Engelstädter
Jan 20, 2010·Trends in Microbiology·Bethany N Kent, Seth R Bordenstein

❮ Previous
Next ❯