Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Benny WekslerJennifer L Sullivan

Abstract

Thymic carcinomas and thymic neuroendocrine tumors are rare diseases often treated with surgical resection. Currently, there are no guidelines regarding nodal dissection at the time of tumor resection. Moreover, the prognostic significance of nodal metastases is unclear. The goal of this study was to define the incidence and prognostic relevance of nodal metastases in patients with thymic carcinoma and thymic neuroendocrine tumors. The Surveillance, Epidemiology and End Results database was queried for patients who underwent surgical resection of thymic carcinoma or a thymic neuroendocrine tumor with documented pathological examination of lymph nodes. The incidence of nodal metastases and the impact on survival were examined. We identified 176 patients with thymic carcinoma and 53 with thymic neuroendocrine tumors. A median of three lymph nodes was sampled per patient. Positive metastasis to at least one lymph node was identified in 92 patients (40.2%). Nodal metastasis was more common in patients with thymic neuroendocrine tumors than in patients with thymic carcinoma (62.3% versus 33.5%). In multivariate analysis, nodal metastasis was more likely in patients with thymic neuroendocrine tumors and with more advanced tumors. The...Continue Reading

References

Dec 12, 2003·The Annals of Thoracic Surgery·Kazuya Kondo, Yasumasa Monden
Dec 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Wouter K de JongHarry J M Groen
Sep 29, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frank C DetterbeckCesar Moran
Nov 13, 2012·The Annals of Thoracic Surgery·Benny WekslerPeter F Ferson
Jun 29, 2013·The Annals of Thoracic Surgery·In Kyu ParkJoo Hyun Kim
Jan 7, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frank C DetterbeckUNKNOWN Participating Institutions of the Thymic Domain
Apr 17, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Enrico RuffiniUNKNOWN European Society of Thoracic Surgeons Thymic Working Group
Jun 24, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z Song, Y Zhang
Oct 14, 2014·The Journal of Thoracic and Cardiovascular Surgery·Pier Luigi FilossoUNKNOWN European Society of Thoracic Surgeons Thymic Group Steering Committee
Nov 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frank C DetterbeckUNKNOWN Participating Institutions of the Thymic Domain
Nov 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Faiz Y BhoraUNKNOWN Advisory Boards
Dec 20, 2014·The Journal of Thoracic and Cardiovascular Surgery·Usman AhmadAndreas Rimner
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisAndrew G Nicholson

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Citations

May 19, 2017·Interactive Cardiovascular and Thoracic Surgery·Zhitao GuUNKNOWN Members of the Chinese Alliance for Research in Thymomas
Sep 18, 2020·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Charles T BakhosAbbas E Abbas
Apr 19, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yang ZhaoHeng Zhao
Dec 29, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wentao FangEnrico Ruffini
Nov 13, 2020·Seminars in Thoracic and Cardiovascular Surgery·Zi-Ming WangMahmoud Ismail
Jun 1, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hugo ClermidyFrançois Tronc
Jun 22, 2021·Interactive Cardiovascular and Thoracic Surgery·Masatsugu HamajiHiroshi Date

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