Impact of positive pleural lavage cytology on survival in patients having lung resection for non-small-cell lung cancer: An international individual patient data meta-analysis

The Journal of Thoracic and Cardiovascular Surgery
Eric LimInternational Pleural Lavage Cytology Collaborators

Abstract

Pleural lavage cytology is the microscopic study of cells obtained from saline instilled into and retrieved from the chest during surgery for non-small-cell lung cancer. The aims of this study were to collate multi-institutional individual patient data for meta-analysis to determine independence as a prognostic marker and to characterize the impact of positive results on stage-adjusted survival. We identified 31 publications from 22 centers/research groups that performed pleural lavage cytology during surgery for non-small-cell lung cancer and invited submission of individual patient data. Actuarial survival was calculated using Kaplan-Meier methods, and comparisons were performed using the log-rank test. Cox proportional hazards regression was used to ascertain the covariates associated with survival. By January 1, 2008, submissions were received internationally from 11 centers with individual data from 8763 patients. In total, 511 (5.8%) patients had a positive pleural lavage cytology result, and this was shown to be an independent predictor of adverse survival associated with a hazard ratio of 1.465 (1.290-1.665; P < .001) compared with a reference hazard ratio of 1 for a negative result. On statistical modeling, the best ad...Continue Reading

References

Mar 1, 1989·Japanese Journal of Cancer Research : Gann·H KondoM Noguchi
Nov 14, 1997·The Annals of Thoracic Surgery·S I KjellbergM Goldberg
Oct 29, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G HillerdalG Gustafsson
Jun 4, 1999·The Annals of Thoracic Surgery·C M DreslerJ Babb
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Y IchinoseUNKNOWN Lung Cancer Surgical Study Sub-Group of the Japan Clinical Oncology Group
Apr 3, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Y IchinoseUNKNOWN Japan Oncology Group
Jul 21, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·C KotoulasA Lioulias
Jan 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Masahiko HigashiyamaHideoki Yokouchi
Feb 28, 2003·The Annals of Thoracic Surgery·Marc RiquetClaire Danel
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Morihito OkadaNoriaki Tsubota
Mar 31, 2004·The Journal of Thoracic and Cardiovascular Surgery·Eric LimPeter Goldstraw
Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·Riichiroh MaruyamaYukito Ichinose
Dec 29, 2004·The Annals of Thoracic Surgery·Giovanni VicidominiVincenzo Pastore
Dec 22, 2005·The Annals of Thoracic Surgery·Sotarou EnatsuKanji Nagai
Dec 23, 2006·The Annals of Thoracic Surgery·Tatsuo NakagawaKotaro Kameyama
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions

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Citations

Apr 26, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pierre MordantMarc Riquet
May 28, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tatsuro OkamotoIchiro Yoshino
Jan 10, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Masanori KanedaYuji Saito
Aug 22, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yasuhiro TsutaniMorihito Okada
Oct 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Valerie W RuschRichard J Cote
Jun 29, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thomas E StinchcombeRamaswamy Govindan
Dec 24, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel Morgensztern, Ramaswamy Govindan
Dec 18, 2013·Seminars in Thoracic and Cardiovascular Surgery·Pierre MordantMarc Riquet
Aug 28, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P Bonnette
Mar 24, 2012·Revue des maladies respiratoires·F Le Pimpec BarthesM Riquet
Dec 3, 2014·The Journal of Thoracic and Cardiovascular Surgery·Diego Gonzalez-Rivas, Ramón Rami-Porta
Sep 1, 2014·The Journal of Thoracic and Cardiovascular Surgery·Kotaro KameyamaUNKNOWN Japanese Joint Committee of Lung Cancer Registry
Apr 26, 2015·Interactive Cardiovascular and Thoracic Surgery·Hiroyuki OgawaMasahiro Yoshimura
Feb 18, 2014·Interactive Cardiovascular and Thoracic Surgery·Naoki YanagawaGen Tamura
Feb 28, 2014·Interactive Cardiovascular and Thoracic Surgery·Tomoyuki NakanoShunsuke Endo
Mar 13, 2015·Interactive Cardiovascular and Thoracic Surgery·Masayuki NakaoSakae Okumura
Sep 14, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ken KodamaTomio Nakayama
May 13, 2014·Surgery Today·Federico MazzaGiovanni Battista Ratto
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter Goldstraw
Feb 20, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeong-Seon RyuSeung-Sik Hwang
Jun 24, 2011·Therapeutic Advances in Respiratory Disease·Kay Choong See, Pyng Lee
Apr 28, 2018·The European Respiratory Journal·Ramón Rami-PortaIvan Vollmer
Jul 11, 2019·General Thoracic and Cardiovascular Surgery·Ken OnoderaYoshinori Okada
Apr 8, 2016·Current Opinion in Pulmonary Medicine·José M Porcel
Nov 3, 2017·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Takashi InoueMasayuki Chida
Oct 29, 2020·General Thoracic and Cardiovascular Surgery·Norikazu KawaiShigeki Taniguchi
Apr 18, 2014·Cancer Discovery·Deborah R CaswellMonte M Winslow
Nov 17, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yusuke FujibayashiWataru Nishio
Sep 26, 2020·The Annals of Thoracic Surgery·Kiyomichi MizunoYasuhisa Ohde
Sep 1, 2013·EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [et Al.]·Jan P van Meerbeeck, Annelies Janssens

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