Impact of post-brentuximab vedotin consolidation on relapsed/refractory CD30+ Hodgkin lymphomas: a large retrospective study on 240 patients enrolled in the French Named-Patient Program

Haematologica
Aurore PerrotLymphoma Study Association (LYSA)

Abstract

Brentuximab vedotin was reported to be effective and safe against refractory/relapsed Hodgkin lymphoma in cohorts of between 12 to 102 patients. Herein we report our retrospective analysis of the French experience with brentuximab vedotin used alone to treat 240 refractory/relapsed Hodgkin lymphoma patients enrolled in a named patient program between 2011 and 2013. All patients had histologically documented CD30+ Hodgkin lymphoma; 74% had refractory disease or early relapses. After a median of 3 lines of chemotherapy, brentuximab vedotin was infused intravenously (1.8 mg/kg every 3 weeks). The primary endpoint was best response. Response at the end of treatment, its duration, survival data and toxicity profile were secondary endpoints. Patients received a median of 6 cycles; 68 underwent a consolidation thereafter. The best response was observed after a median of 4 cycles in 145 (60.4%) patients: 33.8% complete response/unconfirmed complete response, 26.7% partial response. Objective responses were observed as decreased (39.3%) in the 28 patients >60 years. The median response duration was 8.4 months. With median follow-up at 16.1 months, median progression-free survival was 6.8 months and this was significantly longer for pati...Continue Reading

Citations

May 4, 2016·Expert Opinion on Drug Safety·Eunhye Oak, Nancy L Bartlett
Jul 29, 2016·Current Opinion in Oncology·Philippe Lewalle, Sebastian Wittnebel
Feb 22, 2017·Hematological Oncology·Maria K AngelopoulouPanagiotis Tsirigotis
Jul 13, 2018·Expert Opinion on Biological Therapy·Simonetta Viviani, Anna Guidetti
Jan 16, 2018·Blood Research·Jun Ho YiWon Seog Kim
Feb 29, 2020·Therapeutic Advances in Hematology·Theodoros P VassilakopoulosMaria K Angelopoulou
Aug 1, 2019·Cancers·Theodoros P VassilakopoulosKostas Konstantopoulos
Nov 6, 2020·Journal of Blood Medicine·Luca CastagnaCarmelo Carlo-Stella

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