Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika

Nature Communications
Paulina AndradeEva Harris

Abstract

Little is known about enduring memory B cell (MBC) responses to Zika virus (ZIKV) and their relationship with circulating antibodies. Here we comprehensively assess MBC frequency and specificity alongside serum binding and neutralizing antibody responses to ZIKV ~2 weeks and ~8 months postinfection in 31 pediatric subjects with 0, 1 or >1 prior infections with the related dengue virus (DENV). ZIKV infection elicits a robust type-specific MBC response, and the majority of late convalescent anti-ZIKV serum neutralizing activity is attributable to ZIKV-specific antibodies. The number of prior DENV infections does not influence type-specific or cross-reactive MBC responses, although ZIKV has the highest cross-reactivity with DENV3. DENV cross-reactive MBCs expanded by ZIKV infection decline in number and proportion by late convalescence. Finally, ZIKV induces greater cross-reactivity in the MBC pool than in serum antibodies. Our data suggest immunity to DENV only modestly shapes breadth and magnitude of enduring ZIKV antibody responses.

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Aug 15, 2019·Memórias do Instituto Oswaldo Cruz·Renato As OliveiraLaura Hgv Gil
Apr 24, 2019·Tropical Medicine and Infectious Disease·Matthew H Collins
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Jul 20, 2021·Frontiers in Immunology·Anoma NellorePaige M Porrett
Sep 24, 2021·Frontiers in Immunology·Amelia K PintoJames D Brien

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Methods Mentioned

BETA
ELISA
Protein Assay
fluorescence-activated cell sorting
flow cytometry
electrophoresis

Software Mentioned

GraphPad
Prism

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