Abstract
To compare the interstage cardiac catheterization hemodynamic and angiographic findings between shunt types for the Pediatric Heart Network Single Ventricle Reconstruction trial. The trial, which randomized subjects to a modified Blalock-Taussig shunt (MBTS) or right ventricle-to-pulmonary artery shunt (RVPAS) for the Norwood procedure, demonstrated the RVPAS was associated with a smaller pulmonary artery diameter but superior 12-month transplant-free survival. We analyzed the pre-stage II catheterization data for the trial subjects. The hemodynamic variables and shunt and pulmonary angiographic data were compared between shunt types; their association with 12-month transplant-free survival was also evaluated. Of 549 randomized subjects, 389 underwent pre-stage II catheterization. A smaller size, lower aortic and superior vena cava saturation, and higher ventricular end-diastolic pressure were associated with worse 12-month transplant-free survival. The MBTS group had a lower coronary perfusion pressure (27 vs 32 mm Hg; P<.001) and greater pulmonary blood flow/systemic blood flow ratio (1.1 vs 1.0, P=.009). A greater pulmonary blood flow/systemic blood flow ratio increased the risk of death or transplantation only in the RVPAS ...Continue Reading
References
Oct 30, 1999·The Annals of Thoracic Surgery·W I DouglasE L Bove
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·F MigliavaccaM R de Leval
Oct 8, 2003·The Annals of Thoracic Surgery·William T MahleVincent K H Tam
Apr 28, 2004·The Annals of Thoracic Surgery·Anthony AzakieTom R Karl
Sep 1, 2004·The Annals of Thoracic Surgery·Richard G OhyeEdward L Bove
Nov 25, 2004·The Annals of Thoracic Surgery·Shunji SanoMasaaki Kawada
Nov 25, 2004·The Annals of Thoracic Surgery·Christian PizarroWilliam I Norwood
Nov 25, 2004·The Annals of Thoracic Surgery·Yoshihisa TanoueShiro Ishikawa
Apr 26, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Elizabeth M RumballWilliam J Brawn
May 18, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Katarzyna JanuszewskaEdward Malec
Oct 26, 2005·The Annals of Thoracic Surgery·Sarah TabbuttThomas L Spray
Oct 20, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Massimo GriselliWilliam J Brawn
Jan 4, 2007·Pediatrics·Bahaaldin AlsoufiChristopher A Caldarone
Jan 25, 2007·Cardiology in the Young·Eric M GrahamGirish S Shirali
Jul 31, 2007·The Journal of Thoracic and Cardiovascular Surgery·Jean A BallwegSarah Tabbutt
Sep 23, 2008·The Annals of Thoracic Surgery·Joseph CaspiAluizio Stopa
Oct 29, 2008·The Journal of Thoracic and Cardiovascular Surgery·Richard G OhyeUNKNOWN Pediatric Heart Network Investigators
May 28, 2010·The New England Journal of Medicine·Richard G OhyeUNKNOWN Pediatric Heart Network Investigators
Dec 15, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Katarzyna JanuszewskaEdward Malec
Apr 19, 2011·The Journal of Thoracic and Cardiovascular Surgery·Jeffrey H Shuhaiber
Sep 23, 2011·The Annals of Thoracic Surgery·Christoph P HornikSara K Pasquali
Citations
Oct 31, 2015·The Journal of Thoracic and Cardiovascular Surgery·Robert D B Jaquiss
Sep 12, 2015·Congenital Heart Disease·Bryan H GoldsteinLisa Bergersen
Feb 15, 2015·Interactive Cardiovascular and Thoracic Surgery·Mohamed S NassarTarique Hussain
Apr 15, 2015·The Journal of Thoracic and Cardiovascular Surgery·James R BenthamAudrey C Marshall
Nov 27, 2014·Frontiers in Pediatrics·Raoul Roman ArnoldMatthias Gorenflo
Jul 17, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·James WongGerald F Greil
Mar 10, 2017·The Journal of Thoracic and Cardiovascular Surgery·Nicholas D AndersenRobert D B Jaquiss
Nov 13, 2014·Current Opinion in Cardiology·Daniel J DiBardino
Jul 11, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Ray S ChoiMorgan L Brown
Aug 12, 2020·Pediatric Cardiology·Marie VincentiFrank Cetta
Jun 28, 2018·Pediatric Cardiology·Thomas J KulikStephen P Sanders
Mar 10, 2021·Cardiology in the Young·Matthew C SchwartzThomas S Maxey
Jun 1, 2021·Frontiers in Physiology·Jonathan PrimeauxC Alberto Figueroa