Impact of Preeclampsia on the Relationship between Maternal Asthma and Offspring Asthma. An Observation from the VDAART Clinical Trial

American Journal of Respiratory and Critical Care Medicine
Hooman MirzakhaniScott T Weiss

Abstract

Maternal asthma and preeclampsia have independently been reported to be associated with increased asthma incidence in children of affected mothers. Maternal asthma is also associated with increased risk of preeclampsia development. However, the joint effect of these maternal conditions on child asthma risk is unknown. To study whether development of preeclampsia among pregnant women with asthma was associated with higher risk of childhood asthma in the VDAART (Vitamin D Antenatal Asthma Reduction Trial). A total of 806 pregnant women and their offspring at high risk of asthma or atopy, who were followed from VDAART enrollment (10-18 wk of gestation) through the child's third birthday, were included in this cohort analysis. Preeclampsia status was determined by chart review, obstetrician diagnosis, and adjudication by a panel of obstetricians. Child asthma was the main outcome as determined by parental report of a physician diagnosis, and the risk of child asthma was also examined if accompanied by recurrent wheeze. The main risk variable of interest was a four-level ordered variable defined for each mother, with values without asthma without preeclampsia, without asthma with preeclampsia, with asthma without preeclampsia, and w...Continue Reading

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Citations

Apr 28, 2020·American Journal of Respiratory and Critical Care Medicine·Sejal SaglaniAdnan Custovic
Sep 6, 2018·American Journal of Respiratory and Critical Care Medicine·Peter D Sly
May 7, 2019·American Journal of Respiratory and Critical Care Medicine·Hooman MirzakhaniScott T Weiss
Apr 4, 2019·Frontiers in Pediatrics·Andrew Bush
Oct 14, 2020·Scientific Reports·Aishwarya P YadamaHooman Mirzakhani
Oct 11, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Nicola ConlanAli S Khashan

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R Foundation for Statistical Computing

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