Impact of preload and afterload on global and regional right ventricular function and pressure: a quantitative echocardiography study

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Jesper KjaergaardBruce D Johnson

Abstract

Several quantitative echocardiographic measures of global and regional right ventricular (RV) function have been proposed, but knowledge of the impact of increases in preload and afterload is limited. Seventeen healthy participants were exposed to increased preload by rapid infusion of 30 mL/kg of saline over 15 minutes, and to increased afterload simulated in an 16- to 18-hour stay in a controlled hypoxic environment (fractional concentration of oxygen in inspired gas = 12.3%). Two-dimensional, Doppler, and Doppler tissue echocardiography evaluations were performed to evaluate global and regional RV function, with changes evaluated by paired analysis. Peak tricuspid regurgitation velocity increased in both conditions, whereas the RV end-diastolic diameter and acceleration time of the pulmonary forward flow only increased with increased preload and afterload, respectively. Estimates of RV function and contractility remained stable: no changes in the RV isovolumic acceleration (1.6 +/- 0.6 vs 1.6 +/- 0.4 and 1.3 +/- 0.4 cm/s2) or tricuspid annular plane systolic excursion (2.5 +/- 0.4 vs 2.5 +/- 0.3 and 2.6 +/- 0.3 cm) were seen (baseline compared with increased afterload and preload, respectively). The RV index of myocardial pe...Continue Reading

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Citations

Jan 17, 2009·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S A Kleijn, O Kamp
Oct 4, 2006·European Journal of Applied Physiology·Jesper KjaergaardBruce D Johnson
Oct 3, 2007·European Journal of Applied Physiology·Jesper KjaergaardRobert P Frantz
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