Impact of prenatal diagnosis of complex congenital heart disease on neonatal and infant morbidity and mortality

Prenatal Diagnosis
Abhishek ChakrabortySethuraman Swaminathan

Abstract

The objective of this study was to analyze the benefits associated with prenatal diagnosis of complex congenital heart disease (CHD) on preoperative morbidity, 30-day and 1-year mortality in this population. This was a retrospective review of patients with complex CHD born at our tertiary care center over a 10-year period. Date analysis using Student t test and chi-square test. The overall rate of prenatal detection of complex CHD was 68.1%. A steady increase in the number of complex CHD diagnosed prenatally was noted during the study period. The prenatal diagnosis of complex CHD was associated with significant reduction in the incidence of the following preoperative parameters: antibiotic use, mechanical ventilation, inotropic support, hepatic and renal dysfunction, and acidosis. These beneficial effects were more significant in ductal-dependent cardiac anomalies. However, there were no neonatal and infant survival benefits in association with prenatal diagnosis. Prenatal diagnosis of complex CHD leads to improved preoperative morbidity, especially in patients with ductal-dependent cardiac anomalies. No survival benefits were noted with prenatal diagnosis of complex CHD.

References

Jan 1, 1985·American Journal of Epidemiology·C FerenczJ W Downing
Jun 13, 1998·American Journal of Perinatology·R S EapenW H Franklin
Aug 15, 2000·Journal of Epidemiology and Community Health·A RosanoP Mastroiacovo
Mar 30, 2001·The Journal of Thoracic and Cardiovascular Surgery·P M VerheijenG B Bennink
Jun 2, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E GarneUNKNOWN Euroscan Group
Jun 27, 2002·Journal of the American College of Cardiology·Julien I E Hoffman, Samuel Kaplan
Jul 11, 2006·Pediatric Cardiology·Ioannis Germanakis, Stavros Sifakis
Nov 22, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ruben J AchermanAlan J Sacks
Nov 19, 2008·Pediatric Cardiology·Tara M SwansonDoff B McElhinney
Apr 28, 2009·The Journal of Pediatrics·Mark K FriedbergLisa K Hornberger
Feb 19, 2010·Pediatric Cardiology·Allison LeveyIsmee A Williams
Jan 21, 2011·The New England Journal of Medicine·Josef Neu, W Allan Walker
Sep 13, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Gerda SchwedlerHans-Werner Hense
Nov 15, 2011·Journal of the American College of Cardiology·Denise van der LindeJolien W Roos-Hesselink
May 15, 2012·The Journal of Thoracic and Cardiovascular Surgery·Mjaye L MazwiJohn M Costello
Oct 12, 2012·Pediatric Cardiology·Benjamin J LandisIsmee A Williams
Nov 3, 2012·Pediatric Cardiology·Denis J LevyMark S Sklansky
Jan 21, 2014·The American Journal of Cardiology·Lydia K WrightMatthew E Oster
Jul 30, 2014·Pediatrics·Rebecca F LibermanMarlene Anderka
Nov 22, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Sanchita PalSimon J Stanworth
Jul 29, 2015·Pediatrics·Michael D QuartermainRoss M Ungerleider

❮ Previous
Next ❯

Citations

Jul 4, 2019·BMJ Case Reports·Lore NobenRik Vullings
Nov 2, 2019·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Jannel M Phillips, Jennifer N Longoria
Jul 26, 2019·Pediatric Cardiology·Ashutosh AgrawalSudheer R Gorla
May 28, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A E L van NisselrooijM C Haak
Apr 1, 2020·Cardiology in the Young·Daniel Salame-WaxmanNilda Espinola-Zavaleta
Jun 27, 2020·The Journal of Pediatrics·Daniel A CastellanosShaine A Morris
Oct 16, 2021·Journal of Magnetic Resonance Imaging : JMRI·Klas BerggrenErik Hedström
May 22, 2021·The Annals of Thoracic Surgery·Won Young LeeTae-Jin Yun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.