Impact of prenatal immune system disturbances on brain development.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Amrita MadhusudanIrene Knuesel

Abstract

As research into various aging-associated neurodegenerative disorders reveals their immense pathophysiological complexity, the focus is currently shifting from studying changes in an advanced disease state to investigations involving pre-symptomatic periods, possible aberrations in early life, and even abnormalities in brain development. Recent studies on the etiology of schizophrenia and autism spectrum disorders revealed a profound impact of neurodevelopmental disturbances on disease predisposition, onset and progression. Here, we discuss how a prenatal immune challenge can affect the developing brain-with a selective focus on the impact on microglia, the brain's immune cells-and the implications for brain aging and its associated risk of developing Alzheimer's disease.

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Citations

Feb 14, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carol A Colton
May 23, 2014·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ganesan Venkatasubramanian, Monojit Debnath
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Nov 11, 2019·Neuroscience and Biobehavioral Reviews·Paula DesplatsMartin G Frasch
Oct 23, 2021·Frontiers in Immunology·Emma L LewisMichal A Elovitz

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