Impact of preoperative fasting times on blood glucose concentration, ketone bodies and acid-base balance in children younger than 36 months: A prospective observational study

European Journal of Anaesthesiology
Nils DennhardtRobert Sümpelmann

Abstract

In contrast to preoperative fasting guidelines in paediatric anaesthesia, actual fasting times are often too long. The objective of this study was to evaluate the effect of preoperative fasting on glucose concentration, ketone bodies and acid-base balance in children. A prospective, noninterventional, clinical observational study. A single-centre trial, study period from June 2014 to November 2014. One hundred children aged 0 to 36 months scheduled for elective paediatric surgery. Patient demographics, fasting times, haemodynamic data, glucose and ketone body concentrations, and acid-base parameters after induction of anaesthesia were documented using a standardised case report form. Mean fasting period was 7.8 ± 4.5 (3.5 to 20) h, and deviation from guideline (ΔGL) was 3.3 ± 3.2 (-2 to 14) h. Linear regression showed a significant correlation between fasting times and ketone bodies, anion gap, base excess, osmolality as well as bicarbonate (for each, P < 0.05), but not glucose or lactate. In children with ΔGL more than 2 h (54%), ketone bodies, osmolality and anion gap were significantly higher and base excess significantly lower than children with ΔGL less than 2 h (for each, P < 0.05). After prolonged preoperative fasting, c...Continue Reading

References

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Jun 30, 2011·European Journal of Anaesthesiology·Ian SmithUNKNOWN European Society of Anaesthesiology
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Citations

Feb 12, 2017·Journal of Endocrinological Investigation·S Vigili de Kreutzenberg, A Avogaro
Sep 10, 2020·Journal of Diabetes Research·Pouran HajianMahshid Nikooseresht
Jul 5, 2017·Paediatric Anaesthesia·Anne E SümpelmannSebastian G Russo
Mar 28, 2019·Emergency Medicine Australasia : EMA·Robert Millar, Anton Harding
Mar 30, 2019·Current Opinion in Anaesthesiology·Robert SümpelmannLars Witt
May 3, 2019·European Journal of Anaesthesiology·Christiane E BeckLars Witt
Feb 14, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Elsayed AbdelkreemAbdelrahim A Sadek
Apr 26, 2019·European Journal of Anaesthesiology·Christiane E BeckRobert Sümpelmann
Dec 29, 2020·Anesthesiology·Allan F SimpaoPaul A Stricker
May 29, 2021·British Journal of Anaesthesia·Eun-Hee KimJin-Tae Kim
Jul 22, 2021·Anesthesia and Pain Medicine·Alexander R SchmidtJulianne Mendoza
Aug 18, 2021·Anesthesia and Analgesia·Nicola DismaJerrold Lerman
Feb 12, 2017·British Journal of Anaesthesia·S M GreenB S Krauss

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