Impact of prepubertal exposure to dietary protocatechuic acid on the hypothalamic-pituitary-testicular axis in rats

Chemico-biological Interactions
Isaac A AdedaraEbenezer O Farombi

Abstract

Protocatechuic acid (PCA; 3, 4-dihydroxybenzoic acid) is a phenolic compound widely found in many edible fruits, vegetables, grape wine and plant-derived beverages. The present study investigated the impact of PCA on the hypothalamic-pituitary-testicular axis of rats orally treated with PCA during the period of prepubertal development to adulthood. Protocatechuic acid was administered to prepubertal male rats at doses of 0, 5, 10, 50 and 100 mg/kg body for 45 consecutive days. The results revealed no treatment-related changes in the body weight gain and organo-somatic indices of the hypothalamus, testes, epididymis, prostate gland and seminal vesicle in rats administered with PCA when compared with control. However, prepubertal exposure to PCA significantly enhanced antioxidant enzyme activities and glutathione level whereas it markedly decreased biomarkers of inflammation and oxidative stress in the hypothalamus, testes and epididymis of the treated rats. Protocatechuic acid significantly increased circulatory concentrations of luteinizing hormone and follicle-stimulating hormone with concomitant increase in serum and intra-testicular testosterone levels. Moreover, PCA-treated rats exhibited significant increase in marker enzy...Continue Reading

Citations

Nov 28, 2020·Andrologia·Supataechasit YannasithinonSitthichai Iamsaard
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kensuke MitsunariHideki Sakai
Aug 8, 2020·Toxicology·Solomon E OwumiAdegboyega K Oyelere
Jun 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hanan Khaled SleimanGuilherme Barroso Langoni de Freitas
Aug 2, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiao SongDingkun Zhang

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