Impact of presence of antiphospholipid antibodies on in vitro fertilization outcome

Obstetrics & Gynecology Science
Yeon Hee HongSeok Hyun Kim

Abstract

To investigate prevalence of antiphospholipid antibody (APA) in Korean infertile women undergoing the first in vitro fertilization (IVF) treatment and to evaluate the influence of APA on the subsequent IVF outcomes. Two hundred nineteen infertile women who destined the first IVF were prospectively enrolled in 2 infertility centers. Male factor or uterine factor infertility and women with past or current endocrine or immunologic disorders were completely excluded. Plasma concentration of lupus anticoagulant was measured by clot-based method, and anticardiolipin antibody (IgG/IgM), and anti-β2-glycoprotein 1 antibody (IgG/IgM) was measured by enzyme-linked immunosorbent assay method before starting ovarian stimulation for IVF. APA was positive in 13 women (5.9%). Lupus anticoagulant was positive in 2 women (0.9%), anticardiolipin antibody was positive in 7 women (3.2%), and anti-β2-glycoprotein 1 antibody was positive in 4 women (1.8%). In 193 women entering embryo transfer, clinical characteristics and stimulation outcomes were comparable between APA-positive (n=12) and APA-negative group (n=181). The clinical pregnancy rate (66.7% vs. 45.9%), ongoing pregnancy rate (58.3% vs. 37.0%), and miscarriage rate (12.5% vs. 19.3%) were ...Continue Reading

References

Apr 1, 1994·American Journal of Obstetrics and Gynecology·N GleicherV Karande
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Jul 19, 2011·American Journal of Reproductive Immunology : AJRI·Yi-Ping ZhongJing Li
Sep 18, 2014·Lupus·C B Chighizola, G R de Jesus

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Citations

Dec 13, 2019·Lupus·G El HasbaniI Uthman
Feb 23, 2019·International Journal of Molecular Sciences·Mara SimopoulouMichael Koutsilieris
Apr 19, 2019·Reproductive Medicine and Biology·Yasunari MiyagiNobuyoshi Hayashi
Apr 19, 2019·Reproductive Medicine and Biology·Yasunari MiyagiNobuyoshi Hayashi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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