Impact of preterm birth on brain development and long-term outcome: protocol for a cohort study in Scotland.

BMJ Open
James P BoardmanSue Fletcher-Watson

Abstract

Preterm birth is closely associated with altered brain development and is a leading cause of neurodevelopmental, cognitive and behavioural impairments across the life course. We aimed to investigate neuroanatomic variation and adverse outcomes associated with preterm birth by studying a cohort of preterm infants and controls born at term using brain MRI linked to biosamples and clinical, environmental and neuropsychological data. Theirworld Edinburgh Birth Cohort is a prospective longitudinal cohort study at the University of Edinburgh. We plan to recruit 300 infants born at <33 weeks of gestational age (GA) and 100 healthy control infants born after 37 weeks of GA. Multiple domains are assessed: maternal and infant clinical and demographic information; placental histology; immunoregulatory and trophic proteins in umbilical cord and neonatal blood; brain macrostructure and microstructure from structural and diffusion MRI (dMRI); DNA methylation; hypothalamic-pituitary-adrenal axis activity; social cognition, attention and processing speed from eye tracking during infancy and childhood; neurodevelopment; gut and respiratory microbiota; susceptibility to viral infections; and participant experience. Main analyses include creation...Continue Reading

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Citations

Apr 23, 2020·Frontiers in Neurology·Manuel BlesaJames P Boardman
Dec 7, 2020·Cerebral Cortex·Manuel BlesaJames P Boardman
Sep 14, 2020·Brain, Behavior, and Immunity·Gemma SullivanJames P Boardman
Oct 13, 2021·Pediatric Research·Evdoxia ValavaniAthanasios Tsanas

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MATLAB

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